Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification

	Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification
	Zhang, Jun 1; Chen, Duofang 1; Liang, Jimin 1; Xue, Huadan 2; Lei, Jing 2; Wang, Qin 2; Chen, Dongmei 1; Meng, Ming 2; Jin, Zhengyu 2; Tian, Jie 1,3
发表期刊	BIOMEDICAL OPTICS EXPRESS
	2014-06-01
卷号	5 期号:6 页码:1861-1876
文章类型	Article
摘要	Combining two or more imaging modalities to provide complementary information has become commonplace in clinical practice and in preclinical and basic biomedical research. By incorporating the structural information provided by computed tomography (CT) or magnetic resonance imaging (MRI), the ill poseness nature of bioluminescence tomography (BLT) can be reduced significantly, thus improve the accuracies of reconstruction and in vivo quantification. In this paper, we present a small animal imaging system combining multi-view and multi-spectral BLT with MRI. The independent MRI-compatible optical device is placed at the end of the clinical MRI scanner. The small animal is transferred between the light tight chamber of the optical device and the animal coil of MRI via a guide rail during the experiment. After the optical imaging and MRI scanning procedures are finished, the optical images are mapped onto the MRI surface by interactive registration between boundary of optical images and silhouette of MRI. Then, incorporating the MRI structural information, a heterogeneous reconstruction algorithm based on finite element method (FEM) with L-1 normalization is used to reconstruct the position, power and region of the light source. In order to validate the feasibility of the system, we conducted experiments of nude mice model implanted with artificial light source and quantitative analysis of tumor inoculation model with MDA-231-GFP-luc. Preliminary results suggest the feasibility and effectiveness of the prototype system. (C) 2014 Optical Society of America
关键词	Imaging Systems Medical And Biological Imaging Tomographic Imaging
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
关键词[WOS]	DIFFUSE OPTICAL TOMOGRAPHY ; FLUORESCENCE TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; RADIATIVE-TRANSFER ; MOUSE MODELS ; BREAST ; TISSUE ; SIMULATION ; ALGORITHM ; APPROXIMATION
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000337503900013
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4036
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 2.Beijing Union Med Coll Hosp, Beijing 100730, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhang, Jun,Chen, Duofang,Liang, Jimin,et al. Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification[J]. BIOMEDICAL OPTICS EXPRESS,2014,5(6):1861-1876.
APA	Zhang, Jun.,Chen, Duofang.,Liang, Jimin.,Xue, Huadan.,Lei, Jing.,...&Tian, Jie.(2014).Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification.BIOMEDICAL OPTICS EXPRESS,5(6),1861-1876.
MLA	Zhang, Jun,et al."Incorporating MRI structural information into bioluminescence tomography: system, heterogeneous reconstruction and in vivo quantification".BIOMEDICAL OPTICS EXPRESS 5.6(2014):1861-1876.

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