CASIA OpenIR  > 中国科学院分子影像重点实验室
Comparative studies of l(p)-regularization-based reconstruction algorithms for bioluminescence tomography
Zhang, Qitan1; Chen, Xueli1; Qu, Xiaochao1; Liang, Jimin1; Tian, Jie1,2
Source PublicationBIOMEDICAL OPTICS EXPRESS
2012-11-01
Volume3Issue:11Pages:2916-2936
SubtypeArticle
AbstractInverse source reconstruction is the most challenging aspect of bioluminescence tomography (BLT) because of its ill-posedness. Although many efforts have been devoted to this problem, so far, there is no generally accepted method. Due to the ill-posedness property of the BLT inverse problem, the regularization method plays an important role in the inverse reconstruction. In this paper, six reconstruction algorithms based on l(p) regularization are surveyed. The effects of the permissible source region, measurement noise, optical properties, tissue specificity and source locations on the performance of the reconstruction algorithms are investigated using a series of single source experiments. In order to further inspect the performance of the reconstruction algorithms, we present the double sources and the in vivo mouse experiments to study their resolution ability and potential for a practical heterogeneous mouse experiment. It is hoped to provide useful guidance on algorithm development and application in the related fields. (C) 2012 Optical Society of America
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS KeywordOPTICAL TOMOGRAPHY ; MODEL ; REGULARIZATION ; EQUATIONS ; MOUSE ; LIGHT
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000310644700022
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4038
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Qitan,Chen, Xueli,Qu, Xiaochao,et al. Comparative studies of l(p)-regularization-based reconstruction algorithms for bioluminescence tomography[J]. BIOMEDICAL OPTICS EXPRESS,2012,3(11):2916-2936.
APA Zhang, Qitan,Chen, Xueli,Qu, Xiaochao,Liang, Jimin,&Tian, Jie.(2012).Comparative studies of l(p)-regularization-based reconstruction algorithms for bioluminescence tomography.BIOMEDICAL OPTICS EXPRESS,3(11),2916-2936.
MLA Zhang, Qitan,et al."Comparative studies of l(p)-regularization-based reconstruction algorithms for bioluminescence tomography".BIOMEDICAL OPTICS EXPRESS 3.11(2012):2916-2936.
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