Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study

	Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study
	Li, Qiang1 ; Wang, Yarong 1; Zhang, Yi 2; Li, Wei1 ; Yang, Weichuan 1; Zhu, Jia 1; Wu, Ning 1; Chang, Haifeng 1; Zheng, Ying 1; Qin, Wei 2; Zhao, Liyan 3; Yuan, Kai 2; Liu, Jixin 2; Wang, Wei 1; Tian, Jie 1,2,4
发表期刊	BRAIN RESEARCH
	2012-08-21
卷号	1469 期号:2012 页码:63-72
文章类型	Article
摘要	Craving is an important factor in relapse to drug abuse, and cue-induced craving is an especially powerful form of this construct. Neuroimaging methods have been utilized to study drug cue-induced craving and neural correlates in the human brain. However, very few studies have focused on characterizing craving and the neural responses to heroin-related cues in short-term abstinent heroin-dependent patients. Twenty-four heroin-dependent subjects and 20 demographically matched drug-naive subjects participated in this study. An event-related cue-reactivity paradigm was employed, while changes in blood oxygen level-dependent (BOLD) signals were acquired by functional magnetic resonance imaging (fMRI). The heroin-dependent group reported significantly increased craving following exposure to heroin-related cues. Direct comparison between the two groups showed that brain activation to heroin-related minus neutral cues was significantly greater for the heroin-dependent group in the bilateral nucleus accumbens (NAc), caudate, putamen, amygdala, hippocampus/parahippocampus, midcingulate cortex, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), medial frontal gyrus (MeFG), midbrain, thalamus, left anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and subcallosal gyrus. Changes in craving in the heroin-dependent group correlated positively with brain activation in the bilateral NAc, caudate, right putamen, and left ACC. The abstinence duration correlated positively with brain activation in the left caudate and right parahippocampal gyrus. In conclusion, the cue-reactivity paradigm significantly activated neural responses in the mesolimbic dopamine (DA) system and prefrontal cortex (PFC) and induced increased craving in short-term abstinent heroin-dependent patients. We suggest that these response patterns characterize the high vulnerability of relapse in short-term abstinent heroin-dependent subjects. (C) 2012 Elsevier B.V. All rights reserved.
关键词	Abstinence Craving Functional Magnetic Resonance Imaging Heroin Dependence
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	DRUG-ADDICTION ; REWARD CIRCUITRY ; NEURAL RESPONSES ; DORSAL STRIATUM ; SMOKING CUES ; BRAIN FMRI ; ACTIVATION ; DOPAMINE ; CORTEX ; DEPENDENCE
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000308265100007
引用统计	被引频次：98[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4041
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Shaanxi, Peoples R China 2.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian, Peoples R China 3.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Li, Qiang,Wang, Yarong,Zhang, Yi,et al. Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study[J]. BRAIN RESEARCH,2012,1469(2012):63-72.
APA	Li, Qiang.,Wang, Yarong.,Zhang, Yi.,Li, Wei.,Yang, Weichuan.,...&Tian, Jie.(2012).Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study.BRAIN RESEARCH,1469(2012),63-72.
MLA	Li, Qiang,et al."Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study".BRAIN RESEARCH 1469.2012(2012):63-72.

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