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Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study
Li, Qiang1; Wang, Yarong1; Zhang, Yi2; Li, Wei1; Yang, Weichuan1; Zhu, Jia1; Wu, Ning1; Chang, Haifeng1; Zheng, Ying1; Qin, Wei2; Zhao, Liyan3; Yuan, Kai2; Liu, Jixin2; Wang, Wei1; Tian, Jie1,2,4
Source PublicationBRAIN RESEARCH
2012-08-21
Volume1469Issue:2012Pages:63-72
SubtypeArticle
AbstractCraving is an important factor in relapse to drug abuse, and cue-induced craving is an especially powerful form of this construct. Neuroimaging methods have been utilized to study drug cue-induced craving and neural correlates in the human brain. However, very few studies have focused on characterizing craving and the neural responses to heroin-related cues in short-term abstinent heroin-dependent patients. Twenty-four heroin-dependent subjects and 20 demographically matched drug-naive subjects participated in this study. An event-related cue-reactivity paradigm was employed, while changes in blood oxygen level-dependent (BOLD) signals were acquired by functional magnetic resonance imaging (fMRI). The heroin-dependent group reported significantly increased craving following exposure to heroin-related cues. Direct comparison between the two groups showed that brain activation to heroin-related minus neutral cues was significantly greater for the heroin-dependent group in the bilateral nucleus accumbens (NAc), caudate, putamen, amygdala, hippocampus/parahippocampus, midcingulate cortex, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), medial frontal gyrus (MeFG), midbrain, thalamus, left anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and subcallosal gyrus. Changes in craving in the heroin-dependent group correlated positively with brain activation in the bilateral NAc, caudate, right putamen, and left ACC. The abstinence duration correlated positively with brain activation in the left caudate and right parahippocampal gyrus. In conclusion, the cue-reactivity paradigm significantly activated neural responses in the mesolimbic dopamine (DA) system and prefrontal cortex (PFC) and induced increased craving in short-term abstinent heroin-dependent patients. We suggest that these response patterns characterize the high vulnerability of relapse in short-term abstinent heroin-dependent subjects. (C) 2012 Elsevier B.V. All rights reserved.
KeywordAbstinence Craving Functional Magnetic Resonance Imaging Heroin Dependence
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDRUG-ADDICTION ; REWARD CIRCUITRY ; NEURAL RESPONSES ; DORSAL STRIATUM ; SMOKING CUES ; BRAIN FMRI ; ACTIVATION ; DOPAMINE ; CORTEX ; DEPENDENCE
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000308265100007
Citation statistics
Cited Times:51[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4041
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Shaanxi, Peoples R China
2.Xidian Univ, Life Sci Res Ctr, Sch Life Sci & Technol, Xian, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Qiang,Wang, Yarong,Zhang, Yi,et al. Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study[J]. BRAIN RESEARCH,2012,1469(2012):63-72.
APA Li, Qiang.,Wang, Yarong.,Zhang, Yi.,Li, Wei.,Yang, Weichuan.,...&Tian, Jie.(2012).Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study.BRAIN RESEARCH,1469(2012),63-72.
MLA Li, Qiang,et al."Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: An event-related fMRI study".BRAIN RESEARCH 1469.2012(2012):63-72.
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