Dynamic organization of intracellular organelle networks

doi:10.1002/wsbm.1505

CASIA OpenIR > 多模态人工智能系统全国重点实验室 > 计算生物学与机器智能

	Dynamic organization of intracellular organelle networks
	Li, Wenjing 1,2; Zhang, Shuhao 1,2,3; Yang, Ge 1,2,4,5
发表期刊	WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
ISSN	1939-5094
	2020-08-31
页码	20
通讯作者	Yang, Ge(yangge@ucas.edu.cn)
摘要	Intracellular organelles are membrane-bound and biochemically distinct compartments constructed to serve specialized functions in eukaryotic cells. Through extensive interactions, they form networks to coordinate and integrate their specialized functions for cell physiology. A fundamental property of these organelle networks is that they constantly undergo dynamic organization via membrane fusion and fission to remodel their internal connections and to mediate direct material exchange between compartments. The dynamic organization not only enables them to serve critical physiological functions adaptively but also differentiates them from many other biological networks such as gene regulatory networks and cell signaling networks. This review examines this fundamental property of the organelle networks from a systems point of view. The focus is exclusively on homotypic networks formed by mitochondria, lysosomes, endosomes, and the endoplasmic reticulum, respectively. First, key mechanisms that drive the dynamic organization of these networks are summarized. Then, several distinct organizational properties of these networks are highlighted. Next, spatial properties of the dynamic organization of these networks are emphasized, and their functional implications are examined. Finally, some representative molecular machineries that mediate the dynamic organization of these networks are surveyed. Overall, the dynamic organization of intracellular organelle networks is emerging as a fundamental and unifying paradigm in the internal organization of eukaryotic cells. This article is categorized under: Models of Systems Properties and Processes > Cellular Models Analytical and Computational Methods > Computational Methods Laboratory Methods and Technologies > Macromolecular Interactions, Methods Metabolic Diseases > Molecular and Cellular Physiology
关键词	dynamic organization intracellular organelle network molecular machinery organelle interaction systems modeling
DOI	10.1002/wsbm.1505
关键词[WOS]	ENDOPLASMIC-RETICULUM ; AXONAL-TRANSPORT ; LATE ENDOSOMES ; MITOCHONDRIAL FISSION ; MOLECULAR-MECHANISM ; MEMBRANE-PROTEINS ; HOMOTYPIC FUSION ; PLASMA-MEMBRANE ; DYNEIN-DYNACTIN ; SARA ENDOSOMES
收录类别	SCI
语种	英语
资助项目	Chinese Academy of Sciences[292019000056] ; National Natural Science Foundation of China[31971289] ; National Natural Science Foundation of China[91954201] ; National Science Foundation USA[CBET1149494] ; University of Chinese Academy of Sciences[115200M001] ; Beijing Municipal Science & Technology Commission[5202022]
项目资助者	Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Science Foundation USA ; University of Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
WOS记录号	WOS:000564065800001
出版者	WILEY
七大方向——子方向分类	人工智能+科学
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/40503
专题	多模态人工智能系统全国重点实验室_计算生物学与机器智能
通讯作者	Yang, Ge
作者单位	1.Univ Chinese Acad Sci, Sch Artificial Intelligence, Lab Computat Biol & Machine Intelligence, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 3.Nankai Univ, Coll Life Sci, Tianjin, Peoples R China 4.Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA 5.Carnegie Mellon Univ, Dept Computat Biol, Pittsburgh, PA 15213 USA
第一作者单位	模式识别国家重点实验室
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Li, Wenjing,Zhang, Shuhao,Yang, Ge. Dynamic organization of intracellular organelle networks[J]. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE,2020:20.
APA	Li, Wenjing,Zhang, Shuhao,&Yang, Ge.(2020).Dynamic organization of intracellular organelle networks.WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE,20.
MLA	Li, Wenjing,et al."Dynamic organization of intracellular organelle networks".WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2020):20.