Hierarchy of Connectivity-Function Relationship of the Human Cortex Revealed through Predicting Activity across Functional Domains

doi:10.1093/cercor/bhaa063

	Hierarchy of Connectivity-Function Relationship of the Human Cortex Revealed through Predicting Activity across Functional Domains
	Wu, Dongya1,2,3,4 ; Fan, Lingzhong1,2,3,5 ; Song, Ming1,2 ; Wang, Haiyan1,2,3 ; Chu, Congying1,2 ; Yu, Shan1,2,3 ; Jiang, Tianzi1,2,3,5,6,7,8
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
	2020-08-01
卷号	30 期号:8 页码:4607-4616
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
摘要	Many studies showed that anatomical connectivity supports both anatomical and functional hierarchies that span across the primary and association cortices in the cerebral cortex. Even though a structure-function relationship has been indicated to uncouple in the association cortex, it is still unknown whether anatomical connectivity can predict functional activations to the same degree throughout the cortex, and it remains unclear whether a hierarchy of this connectivity-function relationship (CFR) exists across the human cortex. We first addressed whether anatomical connectivity could be used to predict functional activations across different functional domains using multilinear regression models. Then, we characterized the CFR by predicting activity from anatomical connectivity throughout the cortex. We found that there is a hierarchy of CFR between sensory-motor and association cortices. Moreover, this CFR hierarchy was correlated to the functional and anatomical hierarchies, respectively, reflected in functional flexibility and the myelin map. Our results suggest a shared hierarchical mechanism in the cortex, a finding which provides important insights into the anatomical and functional organizations of the human brain.
关键词	anatomical connectivity dMRI fMRI functional activations prediction
DOI	10.1093/cercor/bhaa063
关键词[WOS]	INDIVIDUAL-DIFFERENCES ; DIFFUSION MRI ; HUMAN BRAIN ; PARCELLATION ; FMRI ; TRACTOGRAPHY ; GRADIENTS ; COGNITION ; NETWORKS ; ATLAS
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China[91432302] ; Natural Science Foundation of China[31620103905] ; Natural Science Foundation of China[81501179] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; National Key R&D Program of China[2017YFA0105203] ; Beijing Municipal Science & Technology Commission[Z161100000216152] ; Beijing Municipal Science & Technology Commission[Z181100001518004] ; Beijing Municipal Science & Technology Commission[Z171100000117002] ; Guangdong Pearl River Talents Plan[2016ZT06S220]
项目资助者	Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; Beijing Municipal Science & Technology Commission ; Guangdong Pearl River Talents Plan
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000562454500023
出版者	OXFORD UNIV PRESS INC
七大方向——子方向分类	脑网络分析
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/40512
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Jiang, Tianzi
作者单位	1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Northwest Univ, Sch Informat Sci & Technol, Xian 710069, Peoples R China 5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 6.Univ Elect Sci & Technol China, Chengdu Brain Sci Inst, MOE Key Lab Neuroinformat, Clin Hosp, Chengdu 625014, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 8.Chinese Inst Brain Res, Beijing 102206, Peoples R China
第一作者单位	模式识别国家重点实验室
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Wu, Dongya,Fan, Lingzhong,Song, Ming,et al. Hierarchy of Connectivity-Function Relationship of the Human Cortex Revealed through Predicting Activity across Functional Domains[J]. CEREBRAL CORTEX,2020,30(8):4607-4616.
APA	Wu, Dongya.,Fan, Lingzhong.,Song, Ming.,Wang, Haiyan.,Chu, Congying.,...&Jiang, Tianzi.(2020).Hierarchy of Connectivity-Function Relationship of the Human Cortex Revealed through Predicting Activity across Functional Domains.CEREBRAL CORTEX,30(8),4607-4616.
MLA	Wu, Dongya,et al."Hierarchy of Connectivity-Function Relationship of the Human Cortex Revealed through Predicting Activity across Functional Domains".CEREBRAL CORTEX 30.8(2020):4607-4616.