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What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI
Sun, Jinbo1; Zhu, Yuanqiang1; Yang, Yang1; Jin, Lingmin1; von Deneen, Karen M.1; Qin, Wei1; Tian, Jie1,2
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
Volume2013Issue:1Pages:57-65
SubtypeReview
Abstractde-qi, comprising mostly subjective sensations during acupuncture, is traditionally considered as a very important component for the possible therapeutic effects of acupuncture. However, the neural correlates of de-qi are still unclear. In this paper, we reviewed previous fMRI studies from the viewpoint of the neural responses of de-qi. We searched on Pubmed and identified 111 papers. Fourteen studies distinguishing de-qi and sharp pain and eight studies with the mixed sensations were included in further discussions. We found that the blood oxygenation level-dependent (BOLD) responses associated with de-qi were activation dominated, mainly around cortical areas relevant to the processing of somatosensory or pain signals. More intense and extensive activations were shown for the mixed sensations. Specific activations of sharp pain were also shown. Similar BOLD response patterns between de-qi evoked by acupuncture stimulation and de-qi-like sensations evoked by deep pain stimulation were shown. We reckon that a standardized method of qualification and quantification of de-qi, deeper understanding of grouping strategy of de-qi and sharp pain, and making deep pain stimulation as a control, as well as a series of improvements in the statistical method, are crucial factors for revealing the neural correlates of de-qi and neural mechanisms of acupuncture.
KeywordMusculoskeletal Manipulations Manual Therapies Children Child Pediatrics
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordSOUTHAMPTON NEEDLE SENSATION ; SINGLE-TRIAL FMRI ; FUNCTIONAL MRI ; GLOBAL SIGNAL ; ELECTROACUPUNCTURE STIMULATION ; NEURONAL SPECIFICITY ; EVOKED-POTENTIALS ; HUMAN BRAIN ; ELECTRICAL-STIMULATION ; PAINFUL STIMULATION
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000314954900001
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4052
Collection中国科学院分子影像重点实验室
Corresponding AuthorQin, Wei
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Sun, Jinbo,Zhu, Yuanqiang,Yang, Yang,et al. What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,2013(1):57-65.
APA Sun, Jinbo.,Zhu, Yuanqiang.,Yang, Yang.,Jin, Lingmin.,von Deneen, Karen M..,...&Tian, Jie.(2013).What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013(1),57-65.
MLA Sun, Jinbo,et al."What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2013.1(2013):57-65.
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