What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI

	What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI
	Sun, Jinbo 1; Zhu, Yuanqiang 1; Yang, Yang 1; Jin, Lingmin 1; von Deneen, Karen M.1; Qin, Wei 1; Tian, Jie 1,2
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2013
卷号	2013 期号:1 页码:57-65
文章类型	Review
摘要	de-qi, comprising mostly subjective sensations during acupuncture, is traditionally considered as a very important component for the possible therapeutic effects of acupuncture. However, the neural correlates of de-qi are still unclear. In this paper, we reviewed previous fMRI studies from the viewpoint of the neural responses of de-qi. We searched on Pubmed and identified 111 papers. Fourteen studies distinguishing de-qi and sharp pain and eight studies with the mixed sensations were included in further discussions. We found that the blood oxygenation level-dependent (BOLD) responses associated with de-qi were activation dominated, mainly around cortical areas relevant to the processing of somatosensory or pain signals. More intense and extensive activations were shown for the mixed sensations. Specific activations of sharp pain were also shown. Similar BOLD response patterns between de-qi evoked by acupuncture stimulation and de-qi-like sensations evoked by deep pain stimulation were shown. We reckon that a standardized method of qualification and quantification of de-qi, deeper understanding of grouping strategy of de-qi and sharp pain, and making deep pain stimulation as a control, as well as a series of improvements in the statistical method, are crucial factors for revealing the neural correlates of de-qi and neural mechanisms of acupuncture.
关键词	Musculoskeletal Manipulations Manual Therapies Children Child Pediatrics
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	SOUTHAMPTON NEEDLE SENSATION ; SINGLE-TRIAL FMRI ; FUNCTIONAL MRI ; GLOBAL SIGNAL ; ELECTROACUPUNCTURE STIMULATION ; NEURONAL SPECIFICITY ; EVOKED-POTENTIALS ; HUMAN BRAIN ; ELECTRICAL-STIMULATION ; PAINFUL STIMULATION
收录类别	SCI
语种	英语
WOS研究方向	Integrative & Complementary Medicine
WOS类目	Integrative & Complementary Medicine
WOS记录号	WOS:000314954900001
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4052
专题	中国科学院分子影像重点实验室
通讯作者	Qin, Wei
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Sun, Jinbo,Zhu, Yuanqiang,Yang, Yang,et al. What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,2013(1):57-65.
APA	Sun, Jinbo.,Zhu, Yuanqiang.,Yang, Yang.,Jin, Lingmin.,von Deneen, Karen M..,...&Tian, Jie.(2013).What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013(1),57-65.
MLA	Sun, Jinbo,et al."What Is the de-qi-Related Pattern of BOLD Responses? A Review of Acupuncture Studies in fMRI".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2013.1(2013):57-65.

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