Impact of Global Normalization in fMRI Acupuncture Studies

	Impact of Global Normalization in fMRI Acupuncture Studies
	Sun, Jinbo 1; Qin, Wei 1; Jin, Lingmin 1; Dong, Minghao 1; Yang, Xuejuan 1; Zhu, Yuanqiang 1; Yang, Yang 1; von Deneen, Karen M.1; Gong, Qiyong 2; Tian, Jie 1,3
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2012
卷号	62 期号:2 页码:1216-1220
文章类型	Article
摘要	Global normalization is often used as a preprocessing step for dispelling the "nuisance effects." However, it has been shown in cognitive and emotion tasks that this preprocessing step might greatly distort statistical results when the orthogonality assumption of global normalization is violated. The present study examines this issue in fMRI acupuncture studies. Thirty healthy subjects were recruited to evaluate the impacts of the global normalization on the BOLD responses evoked by acupuncture stimulation during De-qi sensation and tactile stimulation during nonpainful sensations. To this end, we compared results by conducting global normalization (PSGS) and not conducting global normalization (NO PSGS) based on a proportional scaling model. The orthogonality assumption of global normalization was violated, and significant changes between BOLD responses for NO PSGS and PSGS were shown in most subjects. Extensive deactivations of acupuncture in fMRI were the non-specifically pernicious consequences of global normalization. The central responses of acupuncture during De-qi are non-specifically activation-dominant at the somatosensory-related brain network, whose statistical power is specifically enhanced by PSGS. In conclusion, PSGS should be unjustified for acupuncture studies in fMRI. The differences including the global normalization or not may partly contribute to conflicting results and interpretations in previous fMRI acupuncture studies.
关键词	Global Normalization
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	FUNCTIONAL MRI ; DEFAULT MODE ; HUMAN BRAIN ; ELECTROACUPUNCTURE STIMULATION ; COGNITIVE NEUROSCIENCE ; NEURONAL SPECIFICITY ; CORTICAL ACTIVATIONS ; IMPLICATED ACUPOINTS ; EMPIRICAL ANALYSES ; HEALTHY-SUBJECTS
收录类别	SCI
语种	英语
WOS研究方向	Integrative & Complementary Medicine
WOS类目	Integrative & Complementary Medicine
WOS记录号	WOS:000312858300001
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4053
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Sichuan Univ, W China Hosp, Dept Radiol, Huaxi MR Res Ctr HMRRC, Chengdu 610041, Sichuan, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Sun, Jinbo,Qin, Wei,Jin, Lingmin,et al. Impact of Global Normalization in fMRI Acupuncture Studies[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012,62(2):1216-1220.
APA	Sun, Jinbo.,Qin, Wei.,Jin, Lingmin.,Dong, Minghao.,Yang, Xuejuan.,...&Tian, Jie.(2012).Impact of Global Normalization in fMRI Acupuncture Studies.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,62(2),1216-1220.
MLA	Sun, Jinbo,et al."Impact of Global Normalization in fMRI Acupuncture Studies".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 62.2(2012):1216-1220.

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