CASIA OpenIR  > 中国科学院分子影像重点实验室
Impact of Global Normalization in fMRI Acupuncture Studies
Sun, Jinbo1; Qin, Wei1; Jin, Lingmin1; Dong, Minghao1; Yang, Xuejuan1; Zhu, Yuanqiang1; Yang, Yang1; von Deneen, Karen M.1; Gong, Qiyong2; Tian, Jie1,3
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2012
Volume62Issue:2Pages:1216-1220
SubtypeArticle
AbstractGlobal normalization is often used as a preprocessing step for dispelling the "nuisance effects." However, it has been shown in cognitive and emotion tasks that this preprocessing step might greatly distort statistical results when the orthogonality assumption of global normalization is violated. The present study examines this issue in fMRI acupuncture studies. Thirty healthy subjects were recruited to evaluate the impacts of the global normalization on the BOLD responses evoked by acupuncture stimulation during De-qi sensation and tactile stimulation during nonpainful sensations. To this end, we compared results by conducting global normalization (PSGS) and not conducting global normalization (NO PSGS) based on a proportional scaling model. The orthogonality assumption of global normalization was violated, and significant changes between BOLD responses for NO PSGS and PSGS were shown in most subjects. Extensive deactivations of acupuncture in fMRI were the non-specifically pernicious consequences of global normalization. The central responses of acupuncture during De-qi are non-specifically activation-dominant at the somatosensory-related brain network, whose statistical power is specifically enhanced by PSGS. In conclusion, PSGS should be unjustified for acupuncture studies in fMRI. The differences including the global normalization or not may partly contribute to conflicting results and interpretations in previous fMRI acupuncture studies.
KeywordGlobal Normalization
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordFUNCTIONAL MRI ; DEFAULT MODE ; HUMAN BRAIN ; ELECTROACUPUNCTURE STIMULATION ; COGNITIVE NEUROSCIENCE ; NEURONAL SPECIFICITY ; CORTICAL ACTIVATIONS ; IMPLICATED ACUPOINTS ; EMPIRICAL ANALYSES ; HEALTHY-SUBJECTS
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000312858300001
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4053
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Sichuan Univ, W China Hosp, Dept Radiol, Huaxi MR Res Ctr HMRRC, Chengdu 610041, Sichuan, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Sun, Jinbo,Qin, Wei,Jin, Lingmin,et al. Impact of Global Normalization in fMRI Acupuncture Studies[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012,62(2):1216-1220.
APA Sun, Jinbo.,Qin, Wei.,Jin, Lingmin.,Dong, Minghao.,Yang, Xuejuan.,...&Tian, Jie.(2012).Impact of Global Normalization in fMRI Acupuncture Studies.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,62(2),1216-1220.
MLA Sun, Jinbo,et al."Impact of Global Normalization in fMRI Acupuncture Studies".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 62.2(2012):1216-1220.
Files in This Item: Download All
File Name/Size DocType Version Access License
133.Evidence-based c(3033KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sun, Jinbo]'s Articles
[Qin, Wei]'s Articles
[Jin, Lingmin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sun, Jinbo]'s Articles
[Qin, Wei]'s Articles
[Jin, Lingmin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sun, Jinbo]'s Articles
[Qin, Wei]'s Articles
[Jin, Lingmin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 133.Evidence-based complementary and alternative medicine(2012).pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.