Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Resection and survival data from a clinical trial of glioblastoma multiforme-specificIRDye800-BBNfluorescence-guided surgery | |
He, Kunshan1,2 ; Chi, Chongwei2; Li, Deling3,4; Zhang, Jingjing5; Niu, Gang6; Lv, Fangqiao7; Wang, Junmei8; Che, Wenqiang3,4; Zhang, Liwei3,4; Ji, Nan3,4; Zhu, Zhaohui5; Tian, Jie1,2; Chen, Xiaoyuan6
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| Source Publication | BIOENGINEERING & TRANSLATIONAL MEDICINE
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| 2020-08-31 | |
| Pages | 9 |
| Corresponding Author | Ji, Nan(cnpsycho@163.com) ; Zhu, Zhaohui(zhuzhh@pumch.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Chen, Xiaoyuan(chen9647@gmail.com) |
| Abstract | Supra-maximum surgical tumor resection without neurological damage is highly valuable for treatment and prognosis of patients with glioblastoma multiforme (GBM). We developed a GBM-specific fluorescence probe using IRDye800CW (peak absorption/emission, 778/795 nm) and bombesin (BBN), which (IRDye800-BBN) targets the gastrin-releasing peptide receptor, and evaluated the image-guided resection efficiency, sensitivity, specificity, and survivability. Twenty-nine patients with newly diagnosed GBM were enrolled. Sixteen hours preoperatively, IRDye800-BBN (1 mg in 20 ml sterile water) was intravenously administered. A customized fluorescence surgical navigation system was used intraoperatively. Postoperatively, enhanced magnetic resonance images were used to assess the residual tumor volume, calculate the resection extent, and confirm whether complete resection was achieved. Tumor tissues and nonfluorescent brain tissue in adjacent noneloquent boundary areas were harvested and assessed for diagnostic accuracy. Complete resection was achieved in 82.76% of patients. The median extent of resection was 100% (range, 90.6-100%). Eighty-nine samples were harvested, including 70 fluorescence-positive and 19 fluorescence-negative samples. The sensitivity and specificity of IRDye800-BBN were 94.44% (95% CI, 85.65-98.21%) and 88.24% (95% CI, 62.25-97.94%), respectively. Twenty-five patients were followed up (median, 13.5 [3.1-36.0] months), and 14 had died. The mean preoperative and immediate and 6-month postoperative Karnofsky performance scores were 77.9 +/- 11.8, 71.3 +/- 19.2, and 82.6 +/- 14.7, respectively. The median overall and progression-free survival were 23.1 and 14.1 months, respectively. In conclusion, GBM-specific fluorescent IRDye800-BBN can help neurosurgeons identify the tumor boundary with sensitivity and specificity, and may improve survival outcomes. |
| Keyword | fluorescent IRDye800-BBN glioma intraoperative neurosurgery prognosis |
| DOI | 10.1002/btm2.10182 |
| WOS Keyword | HIGH-GRADE GLIOMAS ; 5-AMINOLEVULINIC ACID ; MALIGNANT GLIOMAS ; GUIDED SURGERY ; PEPTIDE RECEPTOR ; SAFE-RESECTION ; FLUORESCENCE |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Beijing Nova program[Z201100006820017] ; Beijing Nova program[Z19111000110000] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1309100] ; National Key R&D Program of China[2016YFC0103803] ; National Key R&D Program of China[2019YFC0120800] ; National Key R&D Program of China[2018YFC0910602] ; National Key R&D Program of China[2017YFA0700401] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81971668] ; National Natural Science Foundation of China[61901472] ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS)[QYZDJ-SSW-JSC005] ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS)[KFJ-STS-ZDTP-059] ; Capital characteristic Clinical Application Project[Z181100001718196] ; China Postdoctoral Science Foundation[2019M660409] ; Clinical Scientist Supporting grant of Beijing Tiantan Hospital[YSP201902] ; National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health |
| Funding Organization | Beijing Nova program ; National Key R&D Program of China ; National Natural Science Foundation of China ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS) ; Capital characteristic Clinical Application Project ; China Postdoctoral Science Foundation ; Clinical Scientist Supporting grant of Beijing Tiantan Hospital ; National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health |
| WOS Research Area | Biotechnology & Applied Microbiology ; Engineering ; Pharmacology & Pharmacy |
| WOS Subject | Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Pharmacology & Pharmacy |
| WOS ID | WOS:000564200800001 |
| Publisher | WILEY |
| Sub direction classification | 医学影像处理与分析 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/40540 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Ji, Nan; Zhu, Zhaohui; Tian, Jie; Chen, Xiaoyuan |
| Affiliation | 1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China 3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 119 South Fourth Ring West Rd, Beijing, Peoples R China 4.China Natl Clin Res Ctr Neurol Dis NCRC ND, Beijing, Peoples R China 5.Chinese Acad Med Sci & Peking Union Med Coll, Dept Nucl Med, Peking Union Med Coll Hosp, 53 Dongdan North St, Beijing, Peoples R China 6.Natl Inst Biomed Imaging & Bioengn NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bldg 35A,Room GD937,35 Convent Dr, Bethesda, MD 20892 USA 7.Capital Med Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing, Peoples R China 8.Capital Med Univ, Beijing Neurosurg Inst, Dept Neuropathol, Beijing, Peoples R China |
| First Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | He, Kunshan,Chi, Chongwei,Li, Deling,et al. Resection and survival data from a clinical trial of glioblastoma multiforme-specificIRDye800-BBNfluorescence-guided surgery[J]. BIOENGINEERING & TRANSLATIONAL MEDICINE,2020:9. |
| APA | He, Kunshan.,Chi, Chongwei.,Li, Deling.,Zhang, Jingjing.,Niu, Gang.,...&Chen, Xiaoyuan.(2020).Resection and survival data from a clinical trial of glioblastoma multiforme-specificIRDye800-BBNfluorescence-guided surgery.BIOENGINEERING & TRANSLATIONAL MEDICINE,9. |
| MLA | He, Kunshan,et al."Resection and survival data from a clinical trial of glioblastoma multiforme-specificIRDye800-BBNfluorescence-guided surgery".BIOENGINEERING & TRANSLATIONAL MEDICINE (2020):9. |
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