Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance

doi:10.1038/s41598-020-61647-2

	Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance
	Zhang, Qian1,2 ; Zeng, Yi1,2,3,4 ; Yang, Taoyi 1
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
	2020-03-13
卷号	10 期号:1 页码:9
通讯作者	Zhang, Qian(q.zhang@ia.ac.cn) ; Zeng, Yi(yi.zeng@ia.ac.cn)
摘要	Interneurons play crucial roles in neocortex associated with high-level cognitive functions; however, the specific division of labor is still under investigation. Interneurons are exceptionally diverse in their morphological appearance and functional properties. In this study, we modify a prefrontal multicolumn circuit in which five subtypes of inhibitory interneurons play distinct roles in the maintenance of transient information. These interneurons are classified according to the extending range of axonal projections. Our work simplifies the division of labor between different types of interneurons for the maintenance of information and the principle of functional redundancy of the brain from the perspective of computational modeling. This model presents a framework to understand the cooperation between different interneurons in a recurrent cortical circuit.
DOI	10.1038/s41598-020-61647-2
关键词[WOS]	INHIBITORY NEURONS ; PYRAMIDAL NEURON ; ORGANIZATION ; MODEL ; SUBNETWORKS ; CONNECTIONS ; COLUMNAR ; RELEASE ; AXON ; RAT
收录类别	SCI
语种	英语
资助项目	Key Research Program of Frontier Sciences, CAS[ZDBS-LY-JSC013] ; Brain-inspired Cognition of Consciousness and Anesthesia[Y8D1051LE1] ; National Natural Science Foundation of China[81501594] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDB32070100] ; Beijing Municipality of Science and Technology[Z181100001518006] ; Major Research Program of Shandong Province[2018CXGC1503]
项目资助者	Key Research Program of Frontier Sciences, CAS ; Brain-inspired Cognition of Consciousness and Anesthesia ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Beijing Municipality of Science and Technology ; Major Research Program of Shandong Province
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000563437800007
出版者	NATURE PUBLISHING GROUP
七大方向——子方向分类	类脑模型与计算
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/40543
专题	脑图谱与类脑智能实验室_类脑认知计算
通讯作者	Zhang, Qian; Zeng, Yi
作者单位	1.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhang, Qian,Zeng, Yi,Yang, Taoyi. Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance[J]. SCIENTIFIC REPORTS,2020,10(1):9.
APA	Zhang, Qian,Zeng, Yi,&Yang, Taoyi.(2020).Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance.SCIENTIFIC REPORTS,10(1),9.
MLA	Zhang, Qian,et al."Computational Investigation of Contributions from Different Subtypes of Interneurons in Prefrontal Cortex for Information Maintenance".SCIENTIFIC REPORTS 10.1(2020):9.