Knowledge Commons of Institute of Automation,CAS
Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients | |
Yuan Lin; Lin-Lin Li; Wei Nie; Xiao lei Liu; Adler, Avital; Chi Xiao; Fujian Lu; Liping Wang; Hua Han; Xianhua Wang; Wen-Biao Gan; Heping Cheng | |
发表期刊 | NATURE COMMUNICATIONS |
2019 | |
期号 | 10页码:13 |
摘要 | Mitochondrial calcium ([Ca2+](mito)) dynamics plays vital roles in regulating fundamental cellular and organellar functions including bioenergetics. However, neuronal [Ca2+](mito) dynamics in vivo and its regulation by brain activity are largely unknown. By performing twophoton Ca2+ imaging in the primary motor (M1) and visual cortexes (V1) of awake behaving mice, we find that discrete [Ca2+](mito) transients occur synchronously over somatic and dendritic mitochondrial network, and couple with cytosolic calcium ([Ca2+](cyto)) transients in a probabilistic, rather than deterministic manner. The amplitude, duration, and frequency of [Ca2+](cyto) transients constitute important determinants of the coupling, and the coupling fidelity is greatly increased during treadmill running (in M1 neurons) and visual stimulation (in V1 neurons). Moreover, Ca2+/calmodulin kinase II is mechanistically involved in modulating the dynamic coupling process. Thus, activity-dependent dynamic [Ca2+](mito)-to[Ca2+] cyto coupling affords an important mechanism whereby [Ca2+](mito) decodes brain activity for the regulation of mitochondrial bioenergetics to meet fluctuating neuronal energy demands as well as for neuronal information processing. |
关键词 | PROTEIN-KINASE-II ESSENTIAL COMPONENT DENDRITIC SPINES MOTOR CORTEX CALCIUM DYSFUNCTION FREQUENCY DYNAMICS DISEASE ER |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/40587 |
专题 | 脑图谱与类脑智能实验室_微观重建与智能分析 中国科学院自动化研究所 |
通讯作者 | Wen-Biao Gan; Heping Cheng |
推荐引用方式 GB/T 7714 | Yuan Lin,Lin-Lin Li,Wei Nie,et al. Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients[J]. NATURE COMMUNICATIONS,2019(10):13. |
APA | Yuan Lin.,Lin-Lin Li.,Wei Nie.,Xiao lei Liu.,Adler, Avital.,...&Heping Cheng.(2019).Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients.NATURE COMMUNICATIONS(10),13. |
MLA | Yuan Lin,et al."Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients".NATURE COMMUNICATIONS .10(2019):13. |
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