CASIA OpenIR  > 中国科学院分子影像重点实验室
Noninvasive Estimation of the Input Function for Dynamic Mouse F-18-FDG MicroPET Studies
Mu, Wei; Chen, Zhe; Dai, Xiaoqian; Tian, Jie
Source PublicationIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
2013-11-01
Volume60Issue:11Pages:3103-3112
SubtypeArticle
AbstractA new noninvasive estimation method for the plasma time-activity curve, i.e., input function (IF) of the tracer kinetic model in dynamic F-18-FDG microPET mouse studies, is proposed and validated. This estimation method comprises of four steps. First, a novel constraint nonnegative matrix factorization segmentation algorithm was applied to extract the left ventricle (Lv) and myocardium (Myo) time activity curves (TACs). Second, we modeled the IF as a seven-parameter mathematical equation and constructed a dual-output model of the real TAC in Lv and Myo accounting for the partial-volume and spillover effects. Then, we fit the image-derived Lv and Myo TACs to the dual-output model to estimate the parameters of the IF. Finally, the IF was validated by comparing it to the gold standard IF while considering the delay and dispersion effects. Our method was verified based on 20 mice datasets from the Mouse Quantitation Program database, provided by UCLA. The error of the areas under the curves between the delayed and dispersed estimated IF and the gold standard IF was 7.237% +/- 6.742% (r = 0.969), and the error of the F-18-FDG influx constant Ki of the Myo was 4.910% +/- 6.810% (r = 0.992). The results demonstrated the effectiveness of the proposed method.
KeywordBayesian Penalty Term Constraint Nonnegative Matrix Factorization (Cnmf) Delay And Dispersion Effects Input Function Partial-volume And Spillover Effects
WOS HeadingsScience & Technology ; Technology
WOS KeywordINDEPENDENT COMPONENT ANALYSIS ; POSITRON-EMISSION-TOMOGRAPHY ; PARTIAL-VOLUME CORRECTION ; BLOOD-SAMPLE ; PET IMAGES ; QUANTIFICATION ; TOOL
Indexed BySCI
Language英语
WOS Research AreaEngineering
WOS SubjectEngineering, Biomedical
WOS IDWOS:000325974500013
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4061
Collection中国科学院分子影像重点实验室
AffiliationChinese Acad Sci, Key Lab Mol Imaging & Funct Imaging, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Mu, Wei,Chen, Zhe,Dai, Xiaoqian,et al. Noninvasive Estimation of the Input Function for Dynamic Mouse F-18-FDG MicroPET Studies[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,2013,60(11):3103-3112.
APA Mu, Wei,Chen, Zhe,Dai, Xiaoqian,&Tian, Jie.(2013).Noninvasive Estimation of the Input Function for Dynamic Mouse F-18-FDG MicroPET Studies.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,60(11),3103-3112.
MLA Mu, Wei,et al."Noninvasive Estimation of the Input Function for Dynamic Mouse F-18-FDG MicroPET Studies".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 60.11(2013):3103-3112.
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