CASIA OpenIR  > 中国科学院分子影像重点实验室
Single photon emission computed tomography-guided Cerenkov luminescence tomography
Hu, Zhenhua1; Chen, Xueli1; Liang, Jimin1; Qu, Xiaochao1; Chen, Duofang1; Yang, Weidong3; Wang, Jing3; Cao, Feng4; Tian, Jie1,2
Source PublicationJOURNAL OF APPLIED PHYSICS
2012-07-15
Volume112Issue:2Pages:-
SubtypeArticle
AbstractCerenkov luminescence tomography (CLT) has become a valuable tool for preclinical imaging because of its ability of reconstructing the three-dimensional distribution and activity of the radiopharmaceuticals. However, it is still far from a mature technology and suffers from relatively low spatial resolution due to the ill-posed inverse problem for the tomographic reconstruction. In this paper, we presented a single photon emission computed tomography (SPECT)-guided reconstruction method for CLT, in which a priori information of the permissible source region (PSR) from SPECT imaging results was incorporated to effectively reduce the ill-posedness of the inverse reconstruction problem. The performance of the method was first validated with the experimental reconstruction of an adult athymic nude mouse implanted with a (NaI)-I-131 radioactive source and an adult athymic nude mouse received an intravenous tail injection of (NaI)-I-131. A tissue-mimic phantom based experiment was then conducted to illustrate the ability of the proposed method in resolving double sources. Compared with the traditional PSR strategy in which the PSR was determined by the surface flux distribution, the proposed method obtained much more accurate and encouraging localization and resolution results. Preliminary results showed that the proposed SPECT-guided reconstruction method was insensitive to the regularization methods and ignored the heterogeneity of tissues which can avoid the segmentation procedure of the organs. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4739266]
Keyword-
WOS HeadingsScience & Technology ; Physical Sciences
WOS KeywordBIOLUMINESCENCE TOMOGRAPHY ; RECONSTRUCTION ; RADIATION ; FEASIBILITY ; SIMULATION ; MODEL ; PET
Indexed BySCI
Language英语
WOS Research AreaPhysics
WOS SubjectPhysics, Applied
WOS IDWOS:000308424500136
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4071
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiang, Jimin; Tian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.Fourth Mil Med Univ, Dept Nucl Med, Xijing Hosp, Xian 710032, Peoples R China
4.Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hu, Zhenhua,Chen, Xueli,Liang, Jimin,et al. Single photon emission computed tomography-guided Cerenkov luminescence tomography[J]. JOURNAL OF APPLIED PHYSICS,2012,112(2):-.
APA Hu, Zhenhua.,Chen, Xueli.,Liang, Jimin.,Qu, Xiaochao.,Chen, Duofang.,...&Tian, Jie.(2012).Single photon emission computed tomography-guided Cerenkov luminescence tomography.JOURNAL OF APPLIED PHYSICS,112(2),-.
MLA Hu, Zhenhua,et al."Single photon emission computed tomography-guided Cerenkov luminescence tomography".JOURNAL OF APPLIED PHYSICS 112.2(2012):-.
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