CASIA OpenIR  > 中国科学院分子影像重点实验室
Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method
Ye, Jinzuo1; Du, Yang1; An, Yu2; Chi, Chongwei1; Tian, Jie1
Source PublicationJOURNAL OF BIOMEDICAL OPTICS
2014-12-01
Volume19Issue:12Pages:-
SubtypeArticle
AbstractFluorescence molecular tomography (FMT) is a promising imaging technique in preclinical research, enabling three-dimensional location of the specific tumor position for small animal imaging. However, FMT presents a challenging inverse problem that is quite ill-posed and ill-conditioned. Thus, the reconstruction of FMT faces various challenges in its robustness and efficiency. We present an FMT reconstruction method based on nonmonotone spectral projected gradient pursuit (NSPGP) with l(1)-norm optimization. At each iteration, a spectral gradient-projection method approximately minimizes a least-squares problem with an explicit onenorm constraint. A nonmonotone line search strategy is utilized to get the appropriate updating direction, which guarantees global convergence. Additionally, the Barzilai-Borwein step length is applied to build the optimal step length, further improving the convergence speed of the proposed method. Several numerical simulation studies, including multisource cases as well as comparative analyses, have been performed to evaluate the performance of the proposed method. The results indicate that the proposed NSPGP method is able to ensure the accuracy, robustness, and efficiency of FMT reconstruction. Furthermore, an in vivo experiment based on a heterogeneous mouse model was conducted, and the results demonstrated that the proposed method held the potential for practical applications of FMT. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
KeywordFluorescence Molecular Tomography Image Reconstruction Inverse Problems Nonmonotone Spectral Projected Gradient Pursuit Tumor Detection In Vivo imagIng
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; ELEMENT BASED TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; SPARSITY REGULARIZATION ; LINE SEARCH ; ALGORITHM ; LIGHT ; INFORMATION ; BARZILAI ; SYSTEM
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000347442600018
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Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4072
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
2.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Ye, Jinzuo,Du, Yang,An, Yu,et al. Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method[J]. JOURNAL OF BIOMEDICAL OPTICS,2014,19(12):-.
APA Ye, Jinzuo,Du, Yang,An, Yu,Chi, Chongwei,&Tian, Jie.(2014).Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method.JOURNAL OF BIOMEDICAL OPTICS,19(12),-.
MLA Ye, Jinzuo,et al."Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method".JOURNAL OF BIOMEDICAL OPTICS 19.12(2014):-.
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