Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method | |
Ye, Jinzuo1; Du, Yang1; An, Yu2; Chi, Chongwei1; Tian, Jie1 | |
发表期刊 | JOURNAL OF BIOMEDICAL OPTICS |
2014-12-01 | |
卷号 | 19期号:12页码:- |
文章类型 | Article |
摘要 | Fluorescence molecular tomography (FMT) is a promising imaging technique in preclinical research, enabling three-dimensional location of the specific tumor position for small animal imaging. However, FMT presents a challenging inverse problem that is quite ill-posed and ill-conditioned. Thus, the reconstruction of FMT faces various challenges in its robustness and efficiency. We present an FMT reconstruction method based on nonmonotone spectral projected gradient pursuit (NSPGP) with l(1)-norm optimization. At each iteration, a spectral gradient-projection method approximately minimizes a least-squares problem with an explicit onenorm constraint. A nonmonotone line search strategy is utilized to get the appropriate updating direction, which guarantees global convergence. Additionally, the Barzilai-Borwein step length is applied to build the optimal step length, further improving the convergence speed of the proposed method. Several numerical simulation studies, including multisource cases as well as comparative analyses, have been performed to evaluate the performance of the proposed method. The results indicate that the proposed NSPGP method is able to ensure the accuracy, robustness, and efficiency of FMT reconstruction. Furthermore, an in vivo experiment based on a heterogeneous mouse model was conducted, and the results demonstrated that the proposed method held the potential for practical applications of FMT. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) |
关键词 | Fluorescence Molecular Tomography Image Reconstruction Inverse Problems Nonmonotone Spectral Projected Gradient Pursuit Tumor Detection In Vivo imagIng |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
关键词[WOS] | DIFFUSE OPTICAL TOMOGRAPHY ; ELEMENT BASED TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; SPARSITY REGULARIZATION ; LINE SEARCH ; ALGORITHM ; LIGHT ; INFORMATION ; BARZILAI ; SYSTEM |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000347442600018 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/4072 |
专题 | 中国科学院分子影像重点实验室 |
作者单位 | 1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China |
推荐引用方式 GB/T 7714 | Ye, Jinzuo,Du, Yang,An, Yu,et al. Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method[J]. JOURNAL OF BIOMEDICAL OPTICS,2014,19(12):-. |
APA | Ye, Jinzuo,Du, Yang,An, Yu,Chi, Chongwei,&Tian, Jie.(2014).Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method.JOURNAL OF BIOMEDICAL OPTICS,19(12),-. |
MLA | Ye, Jinzuo,et al."Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method".JOURNAL OF BIOMEDICAL OPTICS 19.12(2014):-. |
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