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Reconstruction algorithms based on l(1)-norm and l(2)-norm for two imaging models of fluorescence molecular tomography: a comparative study
Yi, Huangjian1; Chen, Duofang1; Li, Wei1; Zhu, Shouping1; Wang, Xiaorui2; Liang, Jimin1; Tian, Jie1,3
Source PublicationJOURNAL OF BIOMEDICAL OPTICS
2013-05-01
Volume18Issue:5Pages:-
SubtypeArticle
AbstractFluorescence molecular tomography (FMT) is an important imaging technique of optical imaging. The major challenge of the reconstruction method for FMT is the ill-posed and underdetermined nature of the inverse problem. In past years, various regularization methods have been employed for fluorescence target reconstruction. A comparative study between the reconstruction algorithms based on l(1)-norm and l(2)-norm for two imaging models of FMT is presented. The first imaging model is adopted by most researchers, where the fluorescent target is of small size to mimic small tissue with fluorescent substance, as demonstrated by the early detection of a tumor. The second model is the reconstruction of distribution of the fluorescent substance in organs, which is essential to drug pharmacokinetics. Apart from numerical experiments, in vivo experiments were conducted on a dual-modality FMT/micro-computed tomography imaging system. The experimental results indicated that l(1)-norm regularization is more suitable for reconstructing the small fluorescent target, while l(2)-norm regularization performs better for the reconstruction of the distribution of fluorescent substance. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
KeywordFluorescence Molecular Tomography Regularization Method Imaging Reconstruction Early Detection Of Tumor Drug Distribution
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; BIOLUMINESCENCE TOMOGRAPHY ; BREAST-CANCER ; IN-VIVO ; SYSTEM ; LIGHT ; METHYLATION ; CT
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000322339900028
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Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4073
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Xidian Univ, Sch Tech Phys, Xian 710071, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yi, Huangjian,Chen, Duofang,Li, Wei,et al. Reconstruction algorithms based on l(1)-norm and l(2)-norm for two imaging models of fluorescence molecular tomography: a comparative study[J]. JOURNAL OF BIOMEDICAL OPTICS,2013,18(5):-.
APA Yi, Huangjian.,Chen, Duofang.,Li, Wei.,Zhu, Shouping.,Wang, Xiaorui.,...&Tian, Jie.(2013).Reconstruction algorithms based on l(1)-norm and l(2)-norm for two imaging models of fluorescence molecular tomography: a comparative study.JOURNAL OF BIOMEDICAL OPTICS,18(5),-.
MLA Yi, Huangjian,et al."Reconstruction algorithms based on l(1)-norm and l(2)-norm for two imaging models of fluorescence molecular tomography: a comparative study".JOURNAL OF BIOMEDICAL OPTICS 18.5(2013):-.
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