CASIA OpenIR  > 中国科学院分子影像重点实验室
Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura
Yuan, Kai1; Zhao, Ling2; Cheng, Ping1; Yu, Dahua1,3; Zhao, Limei1; Dong, Tao1; Xing, Lihong1; Bi, Yanzhi1; Yang, Xuejuan1; von Deneen, Karen M.1; Liang, Fanrong2; Gong, Qiyong4; Qin, Wei1; Tian, Jie1,5
Source PublicationJOURNAL OF PAIN
2013-08-01
Volume14Issue:8Pages:836-844
SubtypeArticle
AbstractThe aim of this study was to investigate the relevance of the basal ganglia (BG) in pathogenesis of migraine by assessing the abnormal volume and resting-state networks of the BG in migraine patients without aura (MWoA). The volume of the subsets in the BG was compared between 40 MWoA and 40 age- and gender-matched healthy controls. The resting-state functional connectivity of BG subsets with abnormal volume was also investigated. Reduced volume in the left caudate and the right nucleus accumbens (NAc) was detected in the migraine group compared with healthy controls; meanwhile, increased functional connectivity between the BG and several brain regions within nociceptive and somatosensory processing pathways was observed. Correlation analysis revealed significant correlations between the volume of the bilateral caudate and right NAc and disease duration. In addition, an increased monthly frequency of migraine attack was associated with increased functional connectivity between the bilateral caudate and left insula, and longer disease duration was correlated with increased functional connectivity between the right NAc and bilateral anterior cingulate cortex. Our results revealed abnormal volume of BG and dysfunctional dynamics during interictal resting state within pain pathways of the BG in MWoA, which validated the association between the BG and migraine.
KeywordMigraine Basal Ganglia Nucleus Accumbens Volume Resting State
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordBRAIN-STEM ACTIVATION ; HEROIN-DEPENDENT INDIVIDUALS ; VOXEL-BASED MORPHOMETRY ; PAIN ; ABNORMALITIES ; DISEASE ; SEGMENTATION ; EXPERIENCE ; DISORDERS ; ANALGESIA
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000323020300007
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4080
Collection中国科学院分子影像重点实验室
Corresponding AuthorQin, Wei
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Inner Mongolia, Peoples R China
4.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol,Ctr Med Imaging, Chengdu, Sichuan, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Kai,Zhao, Ling,Cheng, Ping,et al. Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura[J]. JOURNAL OF PAIN,2013,14(8):836-844.
APA Yuan, Kai.,Zhao, Ling.,Cheng, Ping.,Yu, Dahua.,Zhao, Limei.,...&Tian, Jie.(2013).Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura.JOURNAL OF PAIN,14(8),836-844.
MLA Yuan, Kai,et al."Altered Structure and Resting-State Functional Connectivity of the Basal Ganglia in Migraine Patients Without Aura".JOURNAL OF PAIN 14.8(2013):836-844.
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