CASIA OpenIR  > 中国科学院分子影像重点实验室
Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging
Chen, Xueli1,2; Liang, Jimin1; Qu, Xiaochao1; Hou, Yanbin1; Zhu, Shouping1; Chen, Duofang1; Gao, Xinbo2; Tian, Jie1,3
Source PublicationJOURNAL OF X-RAY SCIENCE AND TECHNOLOGY
2012
Volume20Issue:1Pages:31-44
SubtypeArticle
AbstractWe present a method for mapping the two-dimensional (2D) bioluminescent images (BLIs) onto a three-dimensional (3D) body surface derived from the computed tomography (CT) volume data. This mapping includes two closely-related steps, the spatial registration of the 2D BLIs into the coordinate system of the CT volume data and the light flux recovering on the body surface from BLIs. By labeling markers on the body surface, we proposed an effective registration method to achieve the spatial position alignment. The subsequent light flux recovering is presented based on the inverse process of the free-space light transport model and taking the influence of the camera lens diaphragm into account. Incorporating the mapping procedure into the bioluminescence tomography (BLT) reconstruction, we developed a dual-modality BLT and CT imaging framework to provide both optical and anatomical information. The accuracy of the registration and the light flux recovering methods were evaluated via physical phantom experiments. The registration method was found to have a mean error of 0.41 mm and 0.35 mm in horizontal and vertical direction, and the accuracy of the light flux recovering method was below 5%. Furthermore, we evaluated the performance of the dual-modality BLT/CT imaging framework using a mouse phantom. Preliminary results revealed the potential and feasibility of the dual-modality imaging framework.
KeywordDual-modality Imaging Bioluminescence Tomography (Blt) Computed Tomography (Ct) Spatial Registration Light Flux Recovering
WOS HeadingsScience & Technology ; Technology ; Physical Sciences
WOS KeywordTOMOGRAPHY ; RECONSTRUCTION ; MOUSE ; SIMULATION
Indexed BySCI
Language英语
WOS Research AreaInstruments & Instrumentation ; Optics ; Physics
WOS SubjectInstruments & Instrumentation ; Optics ; Physics, Applied
WOS IDWOS:000301363700004
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4081
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
2.Xidian Univ, Sch Elect Engn, Xian 710126, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Chen, Xueli,Liang, Jimin,Qu, Xiaochao,et al. Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging[J]. JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY,2012,20(1):31-44.
APA Chen, Xueli.,Liang, Jimin.,Qu, Xiaochao.,Hou, Yanbin.,Zhu, Shouping.,...&Tian, Jie.(2012).Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging.JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY,20(1),31-44.
MLA Chen, Xueli,et al."Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging".JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY 20.1(2012):31-44.
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