Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging

	Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging
	Chen, Xueli 1,2; Liang, Jimin 1; Qu, Xiaochao 1; Hou, Yanbin 1; Zhu, Shouping 1; Chen, Duofang 1; Gao, Xinbo 2; Tian, Jie 1,3
发表期刊	JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY
	2012
卷号	20 期号:1 页码:31-44
文章类型	Article
摘要	We present a method for mapping the two-dimensional (2D) bioluminescent images (BLIs) onto a three-dimensional (3D) body surface derived from the computed tomography (CT) volume data. This mapping includes two closely-related steps, the spatial registration of the 2D BLIs into the coordinate system of the CT volume data and the light flux recovering on the body surface from BLIs. By labeling markers on the body surface, we proposed an effective registration method to achieve the spatial position alignment. The subsequent light flux recovering is presented based on the inverse process of the free-space light transport model and taking the influence of the camera lens diaphragm into account. Incorporating the mapping procedure into the bioluminescence tomography (BLT) reconstruction, we developed a dual-modality BLT and CT imaging framework to provide both optical and anatomical information. The accuracy of the registration and the light flux recovering methods were evaluated via physical phantom experiments. The registration method was found to have a mean error of 0.41 mm and 0.35 mm in horizontal and vertical direction, and the accuracy of the light flux recovering method was below 5%. Furthermore, we evaluated the performance of the dual-modality BLT/CT imaging framework using a mouse phantom. Preliminary results revealed the potential and feasibility of the dual-modality imaging framework.
关键词	Dual-modality Imaging Bioluminescence Tomography (Blt) Computed Tomography (Ct) Spatial Registration Light Flux Recovering
WOS标题词	Science & Technology ; Technology ; Physical Sciences
关键词[WOS]	TOMOGRAPHY ; RECONSTRUCTION ; MOUSE ; SIMULATION
收录类别	SCI
语种	英语
WOS研究方向	Instruments & Instrumentation ; Optics ; Physics
WOS类目	Instruments & Instrumentation ; Optics ; Physics, Applied
WOS记录号	WOS:000301363700004
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4081
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China 2.Xidian Univ, Sch Elect Engn, Xian 710126, Shaanxi, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Chen, Xueli,Liang, Jimin,Qu, Xiaochao,et al. Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging[J]. JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY,2012,20(1):31-44.
APA	Chen, Xueli.,Liang, Jimin.,Qu, Xiaochao.,Hou, Yanbin.,Zhu, Shouping.,...&Tian, Jie.(2012).Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging.JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY,20(1),31-44.
MLA	Chen, Xueli,et al."Mapping of bioluminescent images onto CT volume surface for dual-modality BLT and CT imaging".JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY 20.1(2012):31-44.

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