CASIA OpenIR  > 中国科学院分子影像重点实验室
Recent advances in bioluminescence tomography: methodology and system as well as application
Qin, Chenghu1,4; Feng, Jinchao2; Zhu, Shouping3; Ma, Xibo1; Zhong, Jianghong1; Wu, Ping1; Jin, Zhengyu5,6; Tian, Jie1,3
Source PublicationLASER & PHOTONICS REVIEWS
2014
Volume8Issue:1Pages:94-114
SubtypeReview
AbstractOptical molecular imaging has been rapidly developed to noninvasively visualize in vivo physiological and pathological processes involved in normal and suffering organisms at the cellular and molecular levels, in which advanced optical imaging technology and modern molecular biology are being combined to provide a state-of-the-art tool for preclinical biomedical research. Among optical molecular imaging modalities, bioluminescence tomography (BLT) has experienced considerable growth and attracted much attention in recent years for its excellent performance, unique advantages, and high cost-effectiveness. This article focuses on the genesis and development of BLT, especially for its computational methodology, imaging system, and biomedical application. An overview of the advantages and challenges of the conventional planar bioluminescence imaging technique is first described in comparison with currently available molecular imaging modalities. The imaging algorithms for inverse source reconstruction are classified and summarized according to different a priori knowledge, followed by a simple depiction of the uniqueness theorems of BLT solution. Diverse imaging systems for obtaining three-dimensional quantitative information of internal bioluminescent sources are then reviewed. The latest application examples of BLT in tumor study and drug discovery are introduced and compared with other mature imaging technologies. Finally, the paper is concluded and an attractive prospect for BLT ispredicted.
KeywordBioluminescence Tomography Biophotonics Optical Molecular Imaging Inverse Source Reconstruction Optical Imaging Instrument Multimodality Fusion
WOS HeadingsScience & Technology ; Physical Sciences
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; RADIATIVE-TRANSFER EQUATION ; FLUORESCENCE MOLECULAR TOMOGRAPHY ; CERENKOV LUMINESCENCE TOMOGRAPHY ; PROTEIN-PROTEIN INTERACTIONS ; TOTAL-VARIATION MINIMIZATION ; PERMISSIBLE SOURCE REGION ; SPHERICAL-HARMONICS APPROXIMATION ; TOTAL VARIATION REGULARIZATION ; MONTE-CARLO-SIMULATION
Indexed BySCI
Language英语
WOS Research AreaOptics ; Physics
WOS SubjectOptics ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000330596500008
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4082
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing 100190, Peoples R China
2.Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing 100124, Peoples R China
3.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
4.Chinese Acad Sci, Bur Acad Local Cooperat, Beijing 100864, Peoples R China
5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China
6.Peking Union Med Coll, Beijing 100730, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Qin, Chenghu,Feng, Jinchao,Zhu, Shouping,et al. Recent advances in bioluminescence tomography: methodology and system as well as application[J]. LASER & PHOTONICS REVIEWS,2014,8(1):94-114.
APA Qin, Chenghu.,Feng, Jinchao.,Zhu, Shouping.,Ma, Xibo.,Zhong, Jianghong.,...&Tian, Jie.(2014).Recent advances in bioluminescence tomography: methodology and system as well as application.LASER & PHOTONICS REVIEWS,8(1),94-114.
MLA Qin, Chenghu,et al."Recent advances in bioluminescence tomography: methodology and system as well as application".LASER & PHOTONICS REVIEWS 8.1(2014):94-114.
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