Recent advances in bioluminescence tomography: methodology and system as well as application

	Recent advances in bioluminescence tomography: methodology and system as well as application
	Qin, Chenghu 1,4; Feng, Jinchao 2; Zhu, Shouping 3; Ma, Xibo1 ; Zhong, Jianghong 1; Wu, Ping 1; Jin, Zhengyu 5,6; Tian, Jie 1,3
发表期刊	LASER & PHOTONICS REVIEWS
	2014
卷号	8 期号:1 页码:94-114
文章类型	Review
摘要	Optical molecular imaging has been rapidly developed to noninvasively visualize in vivo physiological and pathological processes involved in normal and suffering organisms at the cellular and molecular levels, in which advanced optical imaging technology and modern molecular biology are being combined to provide a state-of-the-art tool for preclinical biomedical research. Among optical molecular imaging modalities, bioluminescence tomography (BLT) has experienced considerable growth and attracted much attention in recent years for its excellent performance, unique advantages, and high cost-effectiveness. This article focuses on the genesis and development of BLT, especially for its computational methodology, imaging system, and biomedical application. An overview of the advantages and challenges of the conventional planar bioluminescence imaging technique is first described in comparison with currently available molecular imaging modalities. The imaging algorithms for inverse source reconstruction are classified and summarized according to different a priori knowledge, followed by a simple depiction of the uniqueness theorems of BLT solution. Diverse imaging systems for obtaining three-dimensional quantitative information of internal bioluminescent sources are then reviewed. The latest application examples of BLT in tumor study and drug discovery are introduced and compared with other mature imaging technologies. Finally, the paper is concluded and an attractive prospect for BLT ispredicted.
关键词	Bioluminescence Tomography Biophotonics Optical Molecular Imaging Inverse Source Reconstruction Optical Imaging Instrument Multimodality Fusion
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	DIFFUSE OPTICAL TOMOGRAPHY ; RADIATIVE-TRANSFER EQUATION ; FLUORESCENCE MOLECULAR TOMOGRAPHY ; CERENKOV LUMINESCENCE TOMOGRAPHY ; PROTEIN-PROTEIN INTERACTIONS ; TOTAL-VARIATION MINIMIZATION ; PERMISSIBLE SOURCE REGION ; SPHERICAL-HARMONICS APPROXIMATION ; TOTAL VARIATION REGULARIZATION ; MONTE-CARLO-SIMULATION
收录类别	SCI
语种	英语
WOS研究方向	Optics ; Physics
WOS类目	Optics ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000330596500008
引用统计	被引频次：51[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4082
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Intelligent Med Res Ctr, Beijing 100190, Peoples R China 2.Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing 100124, Peoples R China 3.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 4.Chinese Acad Sci, Bur Acad Local Cooperat, Beijing 100864, Peoples R China 5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China 6.Peking Union Med Coll, Beijing 100730, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Qin, Chenghu,Feng, Jinchao,Zhu, Shouping,et al. Recent advances in bioluminescence tomography: methodology and system as well as application[J]. LASER & PHOTONICS REVIEWS,2014,8(1):94-114.
APA	Qin, Chenghu.,Feng, Jinchao.,Zhu, Shouping.,Ma, Xibo.,Zhong, Jianghong.,...&Tian, Jie.(2014).Recent advances in bioluminescence tomography: methodology and system as well as application.LASER & PHOTONICS REVIEWS,8(1),94-114.
MLA	Qin, Chenghu,et al."Recent advances in bioluminescence tomography: methodology and system as well as application".LASER & PHOTONICS REVIEWS 8.1(2014):94-114.

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