Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study | |
Zhou, Guangyu1; Liu, Peng1; Wang, Jingjing1 ; Wen, Haixia1; Zhu, Mengbo1; Zhao, Ruixia1; von Deneen, Karen M.1; Zeng, Fang2; Liang, Fanrong2; Gong, Qiyong4; Qin, Wei1; Tian, Jie1,3
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| Source Publication | MAGNETIC RESONANCE IMAGING
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| 2013-07-01 | |
| Volume | 31Issue:6Pages:996-1000 |
| Subtype | Article |
| Abstract | Recently, there is an increasing interest in the study of the role of brain dysfunction in the pathogenesis of symptoms of functional dyspepsia (FD). More specifically, abnormal brain activities in patients with FD during the resting state have been proven by several positron emission tomography (PET) studies. Resting-state functional magnetic resonance imaging (fMRI) is also a valuable tool in investigating spontaneous brain activity abnormalities in pathological conditions. In the present study, we examined the amplitude of low-frequency fluctuations (ALFF) and fractional (f)ALFF changes in patients with FD by using fMRI. Twenty-nine patients with FD and sixteen healthy controls participated in this study. Between-group differences in ALFF/fALFF were examined using a permutation-based nonparametric test after accounting for the gender and age effects. The results revealed a significant between-group difference in fALFF but not in ALFF in multiple brain regions including the right insula, brainstem and cerebellum. Seed-based resting-state functional connectivity analysis revealed that FD patients have increased correlations between the right cerebellum and multiple brain regions including the bilateral brainstem, bilateral cerebellum, bilateral thalamus, left para-/hippocampus, left pallidum and left putamen. Furthermore, fLAFF values in the right insula were positively correlated with the severity of the disease. These findings have provided further evidence of spontaneous brain activity abnormalities in FD patients which might contribute to our understanding of the pathophysiology of the disease. (C) 2013 Elsevier Inc. All rights reserved. |
| Keyword | Functional Dyspepsia Resting-state Functional Magnetic Resonance Imaging Functional Connectivity Low-frequency Fluctuation |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| WOS Keyword | QUALITY-OF-LIFE ; BRAIN-GUT AXIS ; UNITED-STATES ; DISTENSION ; CONNECTIVITY ; POPULATION ; DISORDERS ; OPTIMIZATION ; REGISTRATION ; PREVALENCE |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000320818600024 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/4083 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Tian, Jie |
| Affiliation | 1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu 610075, Sichuan, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Sichuan Univ, West China Hosp, HMRRC, Ctr Med Imaging,Dept Radiol, Chengdu 610075, Sichuan, Peoples R China |
| Corresponding Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Zhou, Guangyu,Liu, Peng,Wang, Jingjing,et al. Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study[J]. MAGNETIC RESONANCE IMAGING,2013,31(6):996-1000. |
| APA | Zhou, Guangyu.,Liu, Peng.,Wang, Jingjing.,Wen, Haixia.,Zhu, Mengbo.,...&Tian, Jie.(2013).Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study.MAGNETIC RESONANCE IMAGING,31(6),996-1000. |
| MLA | Zhou, Guangyu,et al."Fractional amplitude of low-frequency fluctuation changes in functional dyspepsia: A resting-state fMRI study".MAGNETIC RESONANCE IMAGING 31.6(2013):996-1000. |
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| zhouguangyu-s2.0-S07（707KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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