FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients

	FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients
	Feng, Yuanyuan 1; Bai, Lijun 1; Ren, Yanshuang 2; Chen, Shangjie 3; Wang, Hu 1; Zhang, Wensheng1 ; Tian, Jie 1,4
发表期刊	MAGNETIC RESONANCE IMAGING
	2012-06-01
卷号	30 期号:5 页码:672-682
文章类型	Article
摘要	The increased risk for the elderly with mild cognitive impairment (MCI) to progress to Alzheimer's disease makes it an appropriate condition for investigation. While the use of acupuncture as a complementary therapeutic method for treating MCI is popular in certain parts of the world, the underlying mechanism is still elusive. We sought to investigate the acupuncture effects on the functional connectivity throughout the entire brain in MCI patients compared to healthy controls (HC). The functional magnetic resonance imaging experiment was performed with two different paradigms, namely, deep acupuncture (DA) and superficial acupuncture (SA), at acupoint KI3. We first identified regions showing abnormal functional connectivity in the MCI group compared to HC during the resting state and subsequently tested whether these regions could be modulated by acupuncture. Then, we made the comparison of MCI vs. HC to test whether there were any specific modulatory patterns in the poststimulus resting brain between the two groups. Finally, we made the comparisons of DA vs. SA in each group to test the effect of acupuncture with different needling depths. We found the temporal regions (hippocampus, thalamus, fusiform gyms) showing abnormal functional connectivity during the resting state. These regions are implicated in memory encoding and retrieving. Furthermore, we found significant changes in functional connectivity related with the abnormal regions in MCI patients following acupuncture. Compared to MC, the correlations related with the temporal regions were enhanced in the poststimulus resting brain in MCI patients. Compared to SA, significantly increased correlations related with the temporal regions were found for the DA condition. The enhanced correlations in the memory-related brain regions following acupuncture may be related to the purported therapeutically beneficial effects of acupuncture for the treatment of MCI. The heterogeneous modulatory patterns between DA and SA may suggest that deep muscle insertion of acupuncture is necessary to achieve the appreciable clinical effect. (C) 2012 Elsevier Inc. All rights reserved.
关键词	Mild Cognitive Impairment (Mci) Fmri Acupuncture Functional Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; PHYSIOLOGICAL CONDITION ; DEMENTIA ; INTEROCEPTION ; STIMULATION ; SPECIFICITY ; MODULATION ; MEMORY ; SENSE
收录类别	SCI
语种	英语
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000304228300010
引用统计	被引频次：85[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4085
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China 2.Chinese Acad Tradit Med, Dept Radiol, Guanganmen Hosp, Beijing 100053, Peoples R China 3.So Med Univ, Baoan Hosp, Dept Acupuncture & Massage, Shenzhen 518101, Peoples R China 4.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Feng, Yuanyuan,Bai, Lijun,Ren, Yanshuang,et al. FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients[J]. MAGNETIC RESONANCE IMAGING,2012,30(5):672-682.
APA	Feng, Yuanyuan.,Bai, Lijun.,Ren, Yanshuang.,Chen, Shangjie.,Wang, Hu.,...&Tian, Jie.(2012).FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients.MAGNETIC RESONANCE IMAGING,30(5),672-682.
MLA	Feng, Yuanyuan,et al."FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients".MAGNETIC RESONANCE IMAGING 30.5(2012):672-682.

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