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White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study
Yu, Dahua1,2; Yuan, Kai1; Zhao, Ling3; Dong, Minghao1; Liu, Peng1; Yang, Xuejuan1; Liu, Jixin1; Sun, Jinbo1; Zhou, Guangyu1; Xue, Ting1; Zhao, Limei1; Cheng, Ping1; Dong, Tao1; von Deneen, Karen M.1; Qin, Wei1; Tian, Jie1,4
发表期刊NMR IN BIOMEDICINE
2013-09-01
卷号26期号:9页码:1103-1112
文章类型Article
摘要Previous studies have proven that migraine and depression are bidirectionally linked. However, few studies have investigated white matter (WM) integrity affected by depressive symptoms in patients suffering from migraine without aura (MWoA). Forty patients with MWoA were divided into two groups according to their self-rating depression scale (SDS) score in the present study, including 20 in the SDS (+) (SDS>49) group and 20 in the SDS (-) (SDS49) group. Forty healthy participants were also recruited as the control group. Tract-based spatial statistics analyses with multiple diffusion tensor imaging-derived indices [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)] were employed collectively to investigate WM integrity between all patients with MWoA and all healthy controls, between each subgroup (SDS (-) group and SDS (+) group) and healthy controls, and between the SDS (-) and SDS (+) groups. Compared with healthy controls, decreased AD was shown in several WM tracts of the whole MWoA group, SDS (-) group and SDS (+) group. In addition, compared with the SDS (-) group, the SDS (+) group showed decreased FA and increased MD and RD, with conserved AD, including the genu, body and splenium of the corpus callosum, bilateral superior longitudinal fasciculi, the right anterior corona radiata and some other WM tracts, similar to previous findings in depression disorder. Furthermore, mean FA and RD in some of the above-mentioned WM tracts in the SDS (+) group were correlated significantly with SDS scores, including the genu and splenium of the corpus callosum, the right anterior corona radiata and the superior longitudinal fasciculi. Our results suggest that WM integrity may be affected by both depression symptoms (more sensitive as RD) and migraine (more sensitive as AD). The findings may serve as a sensitive biomarker of depression severity in MWoA. Copyright (c) 2013 John Wiley & Sons, Ltd.
关键词Migraine Without Aura (Mwoa) Tract-based Spatial Statistics (Tbss) Depressive Symptoms Corpus Callosum (Cc) Anterior Corona Radiata (Acr) Superior Longitudinal Fasciculi (Slf)
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Technology
关键词[WOS]LATE-LIFE DEPRESSION ; DORSOLATERAL PREFRONTAL CORTEX ; VOXEL-BASED MORPHOMETRY ; BIPOLAR DISORDER ; MAJOR DEPRESSION ; CORPUS-CALLOSUM ; MICROSTRUCTURAL ABNORMALITIES ; GRAY-MATTER ; DIFFUSION ; BRAIN
收录类别SCI
语种英语
WOS研究方向Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS类目Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS记录号WOS:000323078700007
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/4096
专题中国科学院分子影像重点实验室
通讯作者Tian, Jie
作者单位1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Inner Mongolia, Peoples R China
3.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Sichuan, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
通讯作者单位中国科学院自动化研究所
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Yu, Dahua,Yuan, Kai,Zhao, Ling,et al. White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study[J]. NMR IN BIOMEDICINE,2013,26(9):1103-1112.
APA Yu, Dahua.,Yuan, Kai.,Zhao, Ling.,Dong, Minghao.,Liu, Peng.,...&Tian, Jie.(2013).White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study.NMR IN BIOMEDICINE,26(9),1103-1112.
MLA Yu, Dahua,et al."White matter integrity affected by depressive symptoms in migraine without aura: a tract-based spatial statistics study".NMR IN BIOMEDICINE 26.9(2013):1103-1112.
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