Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study

doi:10.1002/nbm.2878

	Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study
	Zhou, Guangyu 1; Liu, Peng 1; Zeng, Fang 2; Yuan, Kai 1; Yu, Dahua 1; von Deneen, Karen M.1; Liang, Fanrong 2; Qin, Wei 1; Tian, Jie 1,3
发表期刊	NMR IN BIOMEDICINE
	2013-04-01
卷号	26 期号:4 页码:410-415
文章类型	Article
摘要	Recent brain imaging studies have emphasized the role of regional brain activity abnormalities in the pathophysiology of functional dyspepsia (FD). However, whether the functional connectivity between brain regions is changed, especially between the cerebral hemispheres, in patients with FD remains unknown. Thus, the present study aimed to examine the interhemispheric resting-state functional connectivity (RSFC) changes in patients with FD. Resting-state functional MRI (fMRI) was performed in 26 patients with FD and in 20 matched healthy controls. An interhemispheric RSFC map was obtained by calculating the Pearson correlation (Fisher Z transformed) between each pair of homotopic voxel time series for each subject. The between-group difference in interhemispheric RSFC was then examined at global and voxelwise levels separately. The global difference in interhemispheric RSFC between groups was tested using the independent two-sample t-test. Voxelwise comparisons were carried out using a permutation-based nonparametric test, and multiple comparisons across space were corrected using the threshold-free cluster enhancement (TFCE) method. The results showed that patients with FD had higher global interhemispheric RSFC than healthy controls (p<0.01). Furthermore, voxelwise analysis revealed that patients with FD had increased interhemispheric RSFC in brain regions including the anterior cingulate cortex, insula and thalamus (p<0.01, TFCE corrected). Our findings provide preliminary evidence of interhemispheric correlation abnormalities in patients with FD and contribute to a better understanding of the pathophysiology of the disease. Copyright (c) 2012 John Wiley & Sons, Ltd.
关键词	Functional Dyspepsia Functional Mri Interhemispheric Functional Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
DOI	10.1002/nbm.2878
关键词[WOS]	BRAIN-GUT AXIS ; GASTRIC DISTENSION ; DISORDERS ; FLUCTUATIONS ; OPTIMIZATION ; REGISTRATION ; VALIDATION ; ACTIVATION ; REGIONS ; ANXIETY
收录类别	SCI
语种	英语
WOS研究方向	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS类目	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS记录号	WOS:000316209200007
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4098
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710126, Shaanxi, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhou, Guangyu,Liu, Peng,Zeng, Fang,et al. Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study[J]. NMR IN BIOMEDICINE,2013,26(4):410-415.
APA	Zhou, Guangyu.,Liu, Peng.,Zeng, Fang.,Yuan, Kai.,Yu, Dahua.,...&Tian, Jie.(2013).Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study.NMR IN BIOMEDICINE,26(4),410-415.
MLA	Zhou, Guangyu,et al."Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study".NMR IN BIOMEDICINE 26.4(2013):410-415.

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