CASIA OpenIR  > 中国科学院分子影像重点实验室
Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study
Zhou, Guangyu1; Liu, Peng1; Zeng, Fang2; Yuan, Kai1; Yu, Dahua1; von Deneen, Karen M.1; Liang, Fanrong2; Qin, Wei1; Tian, Jie1,3
Source PublicationNMR IN BIOMEDICINE
2013-04-01
Volume26Issue:4Pages:410-415
SubtypeArticle
AbstractRecent brain imaging studies have emphasized the role of regional brain activity abnormalities in the pathophysiology of functional dyspepsia (FD). However, whether the functional connectivity between brain regions is changed, especially between the cerebral hemispheres, in patients with FD remains unknown. Thus, the present study aimed to examine the interhemispheric resting-state functional connectivity (RSFC) changes in patients with FD. Resting-state functional MRI (fMRI) was performed in 26 patients with FD and in 20 matched healthy controls. An interhemispheric RSFC map was obtained by calculating the Pearson correlation (Fisher Z transformed) between each pair of homotopic voxel time series for each subject. The between-group difference in interhemispheric RSFC was then examined at global and voxelwise levels separately. The global difference in interhemispheric RSFC between groups was tested using the independent two-sample t-test. Voxelwise comparisons were carried out using a permutation-based nonparametric test, and multiple comparisons across space were corrected using the threshold-free cluster enhancement (TFCE) method. The results showed that patients with FD had higher global interhemispheric RSFC than healthy controls (p<0.01). Furthermore, voxelwise analysis revealed that patients with FD had increased interhemispheric RSFC in brain regions including the anterior cingulate cortex, insula and thalamus (p<0.01, TFCE corrected). Our findings provide preliminary evidence of interhemispheric correlation abnormalities in patients with FD and contribute to a better understanding of the pathophysiology of the disease. Copyright (c) 2012 John Wiley & Sons, Ltd.
KeywordFunctional Dyspepsia Functional Mri Interhemispheric Functional Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1002/nbm.2878
WOS KeywordBRAIN-GUT AXIS ; GASTRIC DISTENSION ; DISORDERS ; FLUCTUATIONS ; OPTIMIZATION ; REGISTRATION ; VALIDATION ; ACTIVATION ; REGIONS ; ANXIETY
Indexed BySCI
Language英语
WOS Research AreaBiophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS SubjectBiophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS IDWOS:000316209200007
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4098
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710126, Shaanxi, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Acupuncture & Tuina Sch, Chengdu, Sichuan, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Zhou, Guangyu,Liu, Peng,Zeng, Fang,et al. Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study[J]. NMR IN BIOMEDICINE,2013,26(4):410-415.
APA Zhou, Guangyu.,Liu, Peng.,Zeng, Fang.,Yuan, Kai.,Yu, Dahua.,...&Tian, Jie.(2013).Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study.NMR IN BIOMEDICINE,26(4),410-415.
MLA Zhou, Guangyu,et al."Increased interhemispheric resting-state functional connectivity in functional dyspepsia: a pilot study".NMR IN BIOMEDICINE 26.4(2013):410-415.
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