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Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer
Ke, Hengte1,2,3; Yue, Xiuli3; Wang, Jinrui1,2; Xing, Sen3; Zhang, Qian4; Dai, Zhifei1,2; Tian, Jie5; Wang, Shumin1,2; Jin, Yushen3
Source PublicationSMALL
2014-03-01
Volume10Issue:6Pages:1220-1227
SubtypeArticle
AbstractThe integration of multimodal contrast-enhanced diagnostic imaging and therapeutic capabilities could utilize imaging guided therapy to plan the treatment strategy based on the diagnostic results and to guide/monitor the therapeutic procedures. Herein, gold nanoshelled perfluorooctylbromide (PFOB) nanocapsules with PEGylation (PGsP NCs) are constructed by oil-in-water emulsion method to form polymeric PFOB nanocapsules, followed by the formation of PEGylated gold nanoshell on the surface. PGsP NCs could not only provide excellent contrast enhancement for dual modal ultrasound and CT imaging in vitro and in vivo, but also serve as efficient photoabsorbers for photothermal ablation of tumors on xenografted nude mouse model. To our best knowledge, this is the first report of gold nanoshell serving as both CT contrast agents and photoabsorbers for photothermal therapy. The novel multifunctional nanomedicine would be of great value to offer more comprehensive diagnostic information to guide more accurate and effective cancer therapy.
KeywordGold Nanoshell Liquid Perfluorocarbon Ultrasound Imaging Ct Imaging Photothermal Therapy
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS KeywordRAY COMPUTED-TOMOGRAPHY ; CONTRAST AGENTS ; MACROPHAGE ENDOCYTOSIS ; OPTICAL-PROPERTIES ; NANOPARTICLES ; HYPERTHERMIA ; RADIATION ; NANOCAGES ; NANORODS ; TUMORS
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000333538000024
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/4111
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
Affiliation1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Life Sci & Technol, Harbin 150080, Peoples R China
4.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
5.Chinese Acad Sci, Intelligent Med Ctr, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Ke, Hengte,Yue, Xiuli,Wang, Jinrui,et al. Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer[J]. SMALL,2014,10(6):1220-1227.
APA Ke, Hengte.,Yue, Xiuli.,Wang, Jinrui.,Xing, Sen.,Zhang, Qian.,...&Jin, Yushen.(2014).Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer.SMALL,10(6),1220-1227.
MLA Ke, Hengte,et al."Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer".SMALL 10.6(2014):1220-1227.
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