A new strategy in drug design of chinese medicine: Theory, method and techniques

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	A new strategy in drug design of chinese medicine: Theory, method and techniques
	Yang Hong-jun; Shen Dan 1; Xu Hai-yu 1; Lu Peng1,2
发表期刊	CHINESE JOURNAL OF INTEGRATIVE MEDICINE
	2012-11-01
卷号	18 期号:11 页码:803-806
文章类型	Editorial Material
摘要	The research and development (R&D) process of Chinese medicine, with one notable feature, clinical application based, is significantly different from which of chemical and biological medicine, from laboratory research to clinics. Besides, compound prescription is another character. Therefore, according to different R&D theories between Chinese and Western medicine, we put forward a new strategy in drug design of Chinese medicine, which focuses on "combination-activity relationship (CAR)", taking prescription discovery, component identification and formula optimization as three key points to identify the drugs of high efficacy and low toxicity. The method of drug design of Chinese medicine includes: new prescription discovery based on clinical data and literature information, component identification based on computing and experimental research, as well as formula optimization based on system modeling. This paper puts forward the concept, research framework and techniques of drug design of Chinese medicine, which embodies the R&D model of Chinese medicine, hoping to support the drug design of Chinese medicine theoretically and technologically.
关键词	Drug Design Of Chinese Medicine Combination-activity Relationship Prescription Discovery Component Identification Formula Optimization System Modeling
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
收录类别	SCI
语种	英语
WOS研究方向	Integrative & Complementary Medicine
WOS类目	Integrative & Complementary Medicine
WOS记录号	WOS:000310224500001
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4151
专题	综合信息系统研究中心
作者单位	1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Inst Automat, Beijing 100290, Peoples R China
推荐引用方式 GB/T 7714	Yang Hong-jun,Shen Dan,Xu Hai-yu,et al. A new strategy in drug design of chinese medicine: Theory, method and techniques[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2012,18(11):803-806.
APA	Yang Hong-jun,Shen Dan,Xu Hai-yu,&Lu Peng.(2012).A new strategy in drug design of chinese medicine: Theory, method and techniques.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,18(11),803-806.
MLA	Yang Hong-jun,et al."A new strategy in drug design of chinese medicine: Theory, method and techniques".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 18.11(2012):803-806.