| A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma | |
Chen, Di1 ; Zhang, Fangbo2; Tang, Shihuan2; Chen, Yan3; Lu, Peng1,2; Wen, Shaoxin1; Zhang, Hongchun3; Liu, Xi1; Chao, Enxiang3; Yang, Hongjun2
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| 发表期刊 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| 2013 | |
| 卷号 | 2013期号:2013页码:595924 |
| 文章类型 | Article |
| 摘要 | Traditional Chinese medicine (TCM) has shown significant efficacy in the treatment of cough variant asthma (CVA), a special type of asthma. However, there is shortage of explanations for relevant mechanism of treatment. As Zhengs differentiation is a critical concept in TCM, it is necessary to explain the mechanism of treatment of Zhengs. Based on TCM clinical cases, this study illustrated the mechanism of the treatment of three remarkably relevant Zhengs for CVA: "FengXieFanFei," "FeiQiShiXuan", and "QiDaoLuanJi." To achieve this goal, five steps were carried out: (1) determining feature Zhengs and corresponding key herbs of CVA by analyses of clinical cases; (2) finding out potential targets of the key herbs and clustering them based on their functional annotations; (3) constructing an ingredient-herb network and an ingredient network; (4) identifying modules of the ingredient network; (5) illustrating the mechanism of the treatment by further mining the latent biological implications within each module. The systematic study reveals that the treatment of "FengXieFanFei," "FeiQiShiXuan," and "QiDaoLuanJi" has effects on the regulation of multiple bioprocesses by herbs containing different ingredients with functions of steroid metabolism regulation, airway inflammation, and ion conduction and transportation. This network-based systematic study will be a good way to boost the scientific understanding of mechanism of the treatment of Zhengs. |
| 关键词 | Systematic Study Zheng Mechanism Cough Variant Asthma |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | TRADITIONAL CHINESE MEDICINE ; ENDOTHELIAL GROWTH-FACTOR ; BIOLOGY APPROACH ; DRUG-METABOLISM ; COMMUNITY STRUCTURE ; DISEASE ; TARGETS ; TOXICITY ; PATHWAYS ; CHILDREN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Integrative & Complementary Medicine |
| WOS类目 | Integrative & Complementary Medicine |
| WOS记录号 | WOS:000327995100001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/4154 |
| 专题 | 综合信息系统研究中心 |
| 通讯作者 | Chao, Enxiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 3.China Japan Friendship Hosp, Beijing 100029, Peoples R China |
| 第一作者单位 | 中国科学院自动化研究所 |
| 推荐引用方式 GB/T 7714 | Chen, Di,Zhang, Fangbo,Tang, Shihuan,et al. A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,2013(2013):595924. |
| APA | Chen, Di.,Zhang, Fangbo.,Tang, Shihuan.,Chen, Yan.,Lu, Peng.,...&Yang, Hongjun.(2013).A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013(2013),595924. |
| MLA | Chen, Di,et al."A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2013.2013(2013):595924. |
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