A Computational Drug-Target Network for Yuanhu Zhitong Prescription

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	A Computational Drug-Target Network for Yuanhu Zhitong Prescription
	Xu, Haiyu 1; Tao, Ye 1,2; Lu, Peng1,3 ; Wang, Peng 2; Zhang, Fangbo 1; Yuan, Yuan 1; Wang, Songsong 4; Xiao, Xuefeng 2; Yang, Hongjun1 ; Huang, Luqi 1
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2013
文章类型	Article
摘要	Yuanhu Zhitong prescription (YZP) is a typical and relatively simple traditional Chinese medicine (TCM), widely used in the clinical treatment of headache, gastralgia, and dysmenorrhea. However, the underlying molecular mechanism of action of YZP is not clear. In this study, based on the previous chemical and metabolite analysis, a complex approach including the prediction of the structure of metabolite, high-throughput in silico screening, and network reconstruction and analysis was developed to obtain a computational drug-target network for YZP. This was followed by a functional and pathway analysis by ClueGO to determine some of the pharmacologic activities. Further, two new pharmacologic actions, antidepressant and antianxiety, of YZP were validated by animal experiments using zebrafish and mice models. The forced swimming test and the tail suspension test demonstrated that YZP at the doses of 4 mg/kg and 8 mg/kg had better antidepressive activity when compared with the control group. The anxiolytic activity experiment showed that YZP at the doses of 100 mg/L, 150 mg/L, and 200 mg/L had significant decrease in diving compared to controls. These results not only shed light on the better understanding of the molecular mechanisms of YZP for curing diseases, but also provide some evidence for exploring the classic TCM formulas for new clinical application.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	TANDEM MASS-SPECTROMETRY ; CHINESE MEDICINE ; PREDICTION ; PAIN ; DEPRESSION ; ZEBRAFISH ; RECEPTOR ; SYSTEM ; MODEL ; MICE
收录类别	SCI
语种	英语
WOS研究方向	Integrative & Complementary Medicine
WOS类目	Integrative & Complementary Medicine
WOS记录号	WOS:000319159700001
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4156
专题	综合信息系统研究中心
作者单位	1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 2.Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Capital Med Univ, Beijing 100069, Peoples R China
推荐引用方式 GB/T 7714	Xu, Haiyu,Tao, Ye,Lu, Peng,et al. A Computational Drug-Target Network for Yuanhu Zhitong Prescription[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA	Xu, Haiyu.,Tao, Ye.,Lu, Peng.,Wang, Peng.,Zhang, Fangbo.,...&Huang, Luqi.(2013).A Computational Drug-Target Network for Yuanhu Zhitong Prescription.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA	Xu, Haiyu,et al."A Computational Drug-Target Network for Yuanhu Zhitong Prescription".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).