A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism

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	A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism
	Dai, Wen 1; Liu, Xi 1; Zhang, Zhichen 2; Chen, Jianxin 3; Guo, Rongjuan 2; Zheng, Hong 2; Jin, Xianglan 2; Wen, Shaoxin1 ; Gao, Yibo1 ; Li, Tiangang 3; Lu, Peng1 ; Zhang, Yunling 2
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2013
文章类型	Article
摘要	Prompt and accurate diagnosis of acute ischemic stroke is critical to seek acute therapy. In traditional Chinese medicine (TCM) science, there is a comprehensive system of diagnosis and medical care of acute ischemic stroke. Here we introduce a two-level model for the analysis of TCM syndrome of acute ischemic stroke. Owing to the limitation of sample size and imbalance, we focused on the analysis of wind-phlegm collateral obstruction syndrome (Feng Tan Yu Zu Zheng). Firstly, a Support-Vector-Machine( SVM-) based diagnostic model was set up through selection of core symptoms. After pairwise undersampling, we improved the performance of prediction and generated the core symptoms-based diagnostic model of wind-phlegm collateral obstruction syndrome. Next, Pathway Pattern-based method and MetaDrug platform were used to shed light on the molecular basis of the significance of core symptoms in three complementary aspects: symptom-gene-pathway multilayer correlation network, enriched pathways, and most relevant interaction network. The integration of diagnostic model and molecular mechanism analysis creates an interesting perspective for better understanding the syndrome. The two-level model would provide a new opportunity for the study of TCM syndromes.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	SUPPORT VECTOR MACHINES ; HUMAN PHENOTYPE ONTOLOGY ; DRUG-METABOLISM ; PREDICTION ; TOXICITY ; EPISODES ; DISEASE ; SYMPTOM ; BRAIN
收录类别	SCI
语种	英语
WOS研究方向	Integrative & Complementary Medicine
WOS类目	Integrative & Complementary Medicine
WOS记录号	WOS:000317506000001
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/4157
专题	综合信息系统研究中心
作者单位	1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Univ Chinese Med, Dongfang Hosp, Beijing 100029, Peoples R China 3.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Dai, Wen,Liu, Xi,Zhang, Zhichen,et al. A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA	Dai, Wen.,Liu, Xi.,Zhang, Zhichen.,Chen, Jianxin.,Guo, Rongjuan.,...&Zhang, Yunling.(2013).A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA	Dai, Wen,et al."A Two-Level Model for the Analysis of Syndrome of Acute Ischemic Stroke: From Diagnostic Model to Molecular Mechanism".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).