Common and unique multimodal covarying patterns in autism spectrum disorder subtypes | |
Qi, Shile1; Morris, Robin2,3; Turner, Jessica A.2,3; Fu, Zening1; Jiang, Rongtao4,5,6; Deramus, Thomas P.1; Zhi, Dongmei4,5,6; Calhoun, Vince D.1; Sui, Jing1,4,5,6,7 | |
发表期刊 | MOLECULAR AUTISM |
ISSN | 2040-2392 |
2020-12-18 | |
卷号 | 11期号:1页码:15 |
摘要 | Background The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD. Methods In this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n = 79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n = 58) and Autistic disorder (n = 92) from ABIDE II were used as discovery cohort, and ABIDE I (n = 400) was used for replication. Results Dorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes. Conclusions Although ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. Limitations This study is male based, which cannot be generalized to the female or the general ASD population. |
关键词 | Heterogeneity Autism spectrum disorder Asperger’ s disorder Pervasive developmental disorder-not otherwise specified (PDD-NOS) Autistic disorder Multimodal fusion |
DOI | 10.1186/s13229-020-00397-4 |
关键词[WOS] | HETEROGENEITY ; DEFICITS ; BRAIN ; NEUROMARKERS ; CONNECTIVITY |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS32040100] ; China Natural Science Foundation[61773380] ; Beijing Municipal Science and Technology Commission[Z181100001518005] ; National Institute of Health[1R01MH117107] ; National Institute of Health[R01EB020407] ; National Institute of Health[1R01EB005846] ; National Institute of Health[1R01MH094524] ; National Institute of Health[P20GM103472] ; National Institute of Health[P30GM122734] ; National Science Foundation[1539067] |
项目资助者 | Strategic Priority Research Program of the Chinese Academy of Sciences ; China Natural Science Foundation ; Beijing Municipal Science and Technology Commission ; National Institute of Health ; National Science Foundation |
WOS研究方向 | Genetics & Heredity ; Neurosciences & Neurology |
WOS类目 | Genetics & Heredity ; Neurosciences |
WOS记录号 | WOS:000595126200001 |
出版者 | BMC |
七大方向——子方向分类 | 脑网络分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/41684 |
专题 | 脑网络组研究 |
通讯作者 | Calhoun, Vince D.; Sui, Jing |
作者单位 | 1.Emory Univ, Georgia Inst Technol, Georgia State Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA 2.Georgia State Univ, Dept Psychol, Atlanta, GA 30302 USA 3.Georgia State Univ, Neurosci Inst, Atlanta, GA 30302 USA 4.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Ctr Excellence Brain Sci, Inst Automat, Beijing 100190, Peoples R China |
通讯作者单位 | 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Qi, Shile,Morris, Robin,Turner, Jessica A.,et al. Common and unique multimodal covarying patterns in autism spectrum disorder subtypes[J]. MOLECULAR AUTISM,2020,11(1):15. |
APA | Qi, Shile.,Morris, Robin.,Turner, Jessica A..,Fu, Zening.,Jiang, Rongtao.,...&Sui, Jing.(2020).Common and unique multimodal covarying patterns in autism spectrum disorder subtypes.MOLECULAR AUTISM,11(1),15. |
MLA | Qi, Shile,et al."Common and unique multimodal covarying patterns in autism spectrum disorder subtypes".MOLECULAR AUTISM 11.1(2020):15. |
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shile qi + Common an(6135KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 |
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