Institutional Repository of Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
| Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives | |
Li, Peng1,2; Jing, Ri-Xing3,4 ; Zhao, Rong-Jiang5; Shi, Le1,2; Sun, Hong-Qiang1,2; Ding, Zengbo6,7; Lin, Xiao1,2,8,9; Lu, Lin1,2,8,9; Fan, Yong10
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| Source Publication | JOURNAL OF PSYCHIATRY & NEUROSCIENCE
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| ISSN | 1180-4882 |
| 2020-11-01 | |
| Volume | 45Issue:6Pages:395-405 |
| Corresponding Author | Lu, Lin(linlu@bjmu.edu.cn) ; Fan, Yong(yong.fan@ieee.org) |
| Abstract | Background Dysfunction of the corticostriatal network has been implicated in the pathophysiology of schizophrenia, but findings are inconsistent within and across imaging modalities. We used multimodal neuroimaging to analyze functional and structural connectivity in the corticostriatal network in people with schizophrenia and unaffected first-degree relatives. Methods We collected resting-state functional magnetic resonance imaging and diffusion tensor imaging scans from people with schizophrenia (n = 47), relatives (n = 30) and controls (n = 49). We compared seed-based functional and structural connectivity across groups within striatal subdivisions defined a priori. Results Compared with controls, people with schizophrenia had altered connectivity between the subdivisions and brain regions in the frontal and temporal cortices and thalamus; relatives showed different connectivity between the subdivisions and the right anterior cingulate cortex (ACC) and the left precuneus. Post-hoc t tests revealed that people with schizophrenia had decreased functional connectivity in the ventral loop (ventral striatum-right ACC) and dorsal loop (executive striatum-right ACC and sensorimotor striatum-right ACC), accompanied by decreased structural connectivity; relatives had reduced functional connectivity in the ventral loop and the dorsal loop (right executive striatum-right ACC) and no significant difference in structural connectivity compared with the other groups. Functional connectivity among people with schizophrenia in the bilateral ventral striatum-right ACC was correlated with positive symptom severity. Limitations The number of relatives included was moderate. Striatal subdivisions were defined based on a relatively low threshold, and structural connectivity was measured based on fractional anisotropy alone. Conclusion Our findings provide insight into the role of hypoconnectivity of the ventral corticostriatal system in people with schizophrenia. |
| DOI | 10.1503/jpn.190015 |
| WOS Keyword | SUBSTANTIA-NIGRA HYPERACTIVITY ; VENTRAL STRIATAL ACTIVATION ; BASAL GANGLIA ; ANTIPSYCHOTIC TREATMENT ; DIFFUSION TRACTOGRAPHY ; COGNITIVE DEFICITS ; NEGATIVE SYMPTOMS ; 1ST-EPISODE ; STATE ; PSYCHOSIS |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Basic Research Program of China[2015CB856400] ; National Natural Science Foundation of China[81501158] ; NIH[EB022573] |
| Funding Organization | National Basic Research Program of China ; National Natural Science Foundation of China ; NIH |
| WOS Research Area | Neurosciences & Neurology ; Psychiatry |
| WOS Subject | Neurosciences ; Psychiatry |
| WOS ID | WOS:000588147000004 |
| Publisher | CMA-CANADIAN MEDICAL ASSOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/41769 |
| Collection | 模式识别国家重点实验室 |
| Corresponding Author | Lu, Lin; Fan, Yong |
| Affiliation | 1.Peking Univ, Hosp 6, Inst Mental Hlth, NHC Key Lab Mental Hlth, Beijing, Peoples R China 2.Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Peking Univ, Dept Alcohol & Drug Dependence, Beijing Hui Long Guan Hosp, Beijing, Peoples R China 6.Peking Univ, Natl Inst Drug Dependence, Beijing, Peoples R China 7.Peking Univ, Beijing Key Lab Drug Dependence, Beijing, Peoples R China 8.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China 9.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China 10.Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA |
| Recommended Citation GB/T 7714 | Li, Peng,Jing, Ri-Xing,Zhao, Rong-Jiang,et al. Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2020,45(6):395-405. |
| APA | Li, Peng.,Jing, Ri-Xing.,Zhao, Rong-Jiang.,Shi, Le.,Sun, Hong-Qiang.,...&Fan, Yong.(2020).Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,45(6),395-405. |
| MLA | Li, Peng,et al."Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 45.6(2020):395-405. |
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