Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia

doi:10.1016/j.neuroscience.2020.08.021

	Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia
	He, Yuwen 1,2; Wu, Shihao 3; Chen, Cheng 3; Fan, Lingzhong4 ; Li, Kaixin 5; Wang, Gaohua 3; Wang, Huiling 3; Zhou, Yuan1,2,6
发表期刊	NEUROSCIENCE
ISSN	0306-4522
	2020-10-15
卷号	446 页码:14-27
通讯作者	Zhou, Yuan(zhouyuan@psych.ac.cn)
摘要	Schizophrenia has prominent functional dysconnectivity, especially in the prefrontal cortex (PFC). However, it is unclear whether in the same group of patients with schizophrenia, PFC functional dysconnectivity appears in an organized manner or is stochastically located in different subregions. By investigating the restingstate functional connectivity (rsFC) of each PFC subregion from the Brainnetome atlas in 40 schizophrenia patients and 40 healthy subjects, we found 24 altered connections in schizophrenia, and the connections were divided into four categories by a clustering analysis: increased connections within the PFC, increased connections between the inferior PFC and the thalamus/striatum, reduced connections between the PFC and the motor control areas, and reduced connections between the orbital PFC and the emotional perception regions. In addition, the four categories of rsFC showed distinct cognitive engagement patterns. Our findings suggest that PFC subregions have specific functional dysconnectivity patterns in schizophrenia and may reflect heterogeneous symptoms and cognitive deficits in schizophrenia. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
关键词	prefrontal cortex schizophrenia Brief Assessment of Cognition in Schizophrenia dysconnectivity hypothesis resting-state functional connectivity
DOI	10.1016/j.neuroscience.2020.08.021
关键词[WOS]	NEUROLOGICAL SOFT SIGNS ; BRAIN NETWORKS ; PARANOID SCHIZOPHRENIA ; WORKING-MEMORY ; HEAD MOTION ; CONNECTIVITY ; FMRI ; DYSFUNCTION ; ASSOCIATION ; COGNITION
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81771473] ; National Natural Science Foundation of China[81371476] ; National Natural Science Foundation of China[91432302]
项目资助者	National Natural Science Foundation of China
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000577243000002
出版者	PERGAMON-ELSEVIER SCIENCE LTD
七大方向——子方向分类	脑网络分析
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/42108
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Zhou, Yuan
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, 16 Lincui Rd, Beijing 100101, Peoples R China 3.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Harbin Univ Sci & Technol, Harbin 150080, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	He, Yuwen,Wu, Shihao,Chen, Cheng,et al. Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia[J]. NEUROSCIENCE,2020,446:14-27.
APA	He, Yuwen.,Wu, Shihao.,Chen, Cheng.,Fan, Lingzhong.,Li, Kaixin.,...&Zhou, Yuan.(2020).Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia.NEUROSCIENCE,446,14-27.
MLA	He, Yuwen,et al."Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia".NEUROSCIENCE 446(2020):14-27.