CASIA OpenIR
Altered large-scale functional brain networks in neurological Wilson's disease
Jing, Rixing1,2; Han, Yongsheng3; Cheng, Hewei4; Han, Yongzhu3; Wang, Kai5; Weintraub, Daniel6; Fan, Yong7
Source PublicationBRAIN IMAGING AND BEHAVIOR
ISSN1931-7557
2020-10-01
Volume14Issue:5Pages:1445-1455
Corresponding AuthorFan, Yong(yong.fan@ieee.org)
AbstractWilson's disease patients with neurological symptoms have motor symptoms and cognitive deficits, including frontal executive, visuospatial processing, and memory impairments. Although the brain structural abnormalities associated with Wilson's disease have been documented, it remains largely unknown how Wilson's disease affects large-scale functional brain networks. In this study, we investigated functional brain networks in Wilson's disease. Particularly, we analyzed resting state functional magnetic resonance images of 30 Wilson's disease patients and 26 healthy controls. First, functional brain networks for each participant were extracted using an independent component analysis method. Then, a computationally efficient pattern classification method was developed to identify discriminative brain functional networks associated with Wilson's disease. Experimental results indicated that Wilson's disease patients, compared with healthy controls, had altered large-scale functional brain networks, including the dorsal anterior cingulate cortex and basal ganglia network, the middle frontal gyrus, the dorsal striatum, the inferior parietal lobule, the precuneus, the temporal pole, and the posterior lobe of cerebellum. Classification models built upon these networks distinguished between neurological WD patients and HCs with accuracy up to 86.9% (specificity: 86.7%, sensitivity: 89.7%). The classification scores were correlated with the United Wilson's Disease Rating Scale measures and durations of disease of the patients. These results suggest that Wilson's disease patients have multiple aberrant brain functional networks, and classification scores derived from these networks are associated with severity of clinical symptoms.
KeywordWilson's disease Large-scale functional brain networks Functional magnetic resonance images Machine learning Biomarkers
DOI10.1007/s11682-019-00066-y
WOS KeywordDEFAULT-MODE NETWORK ; WHITE-MATTER ; PARKINSONS-DISEASE ; COGNITIVE PROFILE ; VERBAL FLUENCY ; RATING-SCALE ; CONNECTIVITY ; MRI ; RELIABILITY ; IMPAIRMENT
Indexed BySCI
Language英语
Funding ProjectNational Basic Research Program of China[2015CB856404] ; National Natural Science Foundation of China[61473296] ; Clinical Research Key Project of Anhui University of Chinese Medicine[2014lckf02006] ; Anhui Provincial Science and Technology Project[15011d04009] ; NIH[EB022573] ; NIH[DA039215] ; NIH[DA039002]
Funding OrganizationNational Basic Research Program of China ; National Natural Science Foundation of China ; Clinical Research Key Project of Anhui University of Chinese Medicine ; Anhui Provincial Science and Technology Project ; NIH
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000579512100014
PublisherSPRINGER
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/42166
Collection中国科学院自动化研究所
Corresponding AuthorFan, Yong
Affiliation1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Anhui Univ Chinese Med, Inst Neurol, Hefei, Anhui, Peoples R China
4.Chongqing Univ Posts & Telecommun, Sch Bioinformat, Dept Biomed Engn, Chongqing, Peoples R China
5.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Hefei, Anhui, Peoples R China
6.Univ Penn, Sect Geriatr Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA
7.Univ Penn, Dept Radiol, Perelman Sch Med, Philadelphia, PA 19104 USA
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jing, Rixing,Han, Yongsheng,Cheng, Hewei,et al. Altered large-scale functional brain networks in neurological Wilson's disease[J]. BRAIN IMAGING AND BEHAVIOR,2020,14(5):1445-1455.
APA Jing, Rixing.,Han, Yongsheng.,Cheng, Hewei.,Han, Yongzhu.,Wang, Kai.,...&Fan, Yong.(2020).Altered large-scale functional brain networks in neurological Wilson's disease.BRAIN IMAGING AND BEHAVIOR,14(5),1445-1455.
MLA Jing, Rixing,et al."Altered large-scale functional brain networks in neurological Wilson's disease".BRAIN IMAGING AND BEHAVIOR 14.5(2020):1445-1455.
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