Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma

doi:10.1021/acsnano.0c04341

	Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma
	Wang, Yaqin 1; Shang, Wenting2 ; Zhong, Hongshan 1; Luo, Ting 1; Niu, Meng 1; Xu, Ke 1; Tian, Jie 2,3
发表期刊	ACS NANO
ISSN	1936-0851
	2020-11-24
卷号	14 期号:11 页码:14907-14918
通讯作者	Niu, Meng(guanjh@cmu.edu.cn) ; Xu, Ke(kxu@cmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
摘要	Vessel embolization is recommended as the first line treatment for unresectable hepatocellular carcinoma (HCC). However, owing to the imprecise vessel embolization and heterogeneous response performance among patients, its survival benefits are often compromised. Herein, we reported an innovative strategy to extensively embolize the tumor by triggering the coagulation cascade, and predict the embolization effect with vessel density assessment. We synthesized manganese dioxide (MnO2)/verteporfin (BPD) nanocomposites, in which BPD bound to the tumor vessel endothelial cells (TVECs) and MnO2 nanosheets served as the carrier. MnO2 was reduced to Mn2+ ions and self-assembled with BPD to produce nanoBPD, resulting in enhanced TVECs apoptosis and coagulation cascade compared to that with free BPD. Furthermore, multimodal imaging was used to visualize tumor vessel density, which can be used as a predictor to identify the patients who would benefit from embolization. Our findings describe a promising strategy for both tumor eradication and effect prediction to improve survival benefits in unresectable HCC patients.
关键词	coagulation cascade tumor embolism vessel density hepatocellular carcinoma self-assemble nanoparticle
DOI	10.1021/acsnano.0c04341
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2017YFA0700401] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81630053] ; National Natural Science Foundation of China[81971680] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81601584] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81771944] ; Chinese Academy of Sciences[XDB01030200]
项目资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000595533800041
出版者	AMER CHEMICAL SOC
七大方向——子方向分类	其他
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/42585
专题	中国科学院分子影像重点实验室
通讯作者	Niu, Meng; Xu, Ke; Tian, Jie
作者单位	1.China Med Univ, Dept Intervent Radiol, Affiliated Hosp 1, Shenyang 110000, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Wang, Yaqin,Shang, Wenting,Zhong, Hongshan,et al. Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma[J]. ACS NANO,2020,14(11):14907-14918.
APA	Wang, Yaqin.,Shang, Wenting.,Zhong, Hongshan.,Luo, Ting.,Niu, Meng.,...&Tian, Jie.(2020).Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma.ACS NANO,14(11),14907-14918.
MLA	Wang, Yaqin,et al."Tumor Vessel Targeted Self-Assemble Nanoparticles for Amplification and Prediction of the Embolization Effect in Hepatocellular Carcinoma".ACS NANO 14.11(2020):14907-14918.