| Selective Participation of Single Cortical Neurons in Neuronal Avalanches | |
Bellay, Timothy1,2; Shew, Woodrow L.1,3; Yu, Shan1,4 ; Falco-Walter, Jessica J.1,5; Plenz, Dietmar1
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| 发表期刊 | FRONTIERS IN NEURAL CIRCUITS
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| 2021-01-22 | |
| 卷号 | 14页码:18 |
| 通讯作者 | Plenz, Dietmar(plenzd@mail.nih.gov) |
| 摘要 | Neuronal avalanches are scale-invariant neuronal population activity patterns in the cortex that emerge in vivo in the awake state and in vitro during balanced excitation and inhibition. Theory and experiments suggest that avalanches indicate a state of cortex that improves numerous aspects of information processing by allowing for the transient and selective formation of local as well as system-wide spanning neuronal groups. If avalanches are indeed involved with information processing, one might expect that single neurons would participate in avalanche patterns selectively. Alternatively, all neurons could participate proportionally to their own activity in each avalanche as would be expected for a population rate code. Distinguishing these hypotheses, however, has been difficult as robust avalanche analysis requires technically challenging measures of their intricate organization in space and time at the population level, while also recording sub- or suprathreshold activity from individual neurons with high temporal resolution. Here, we identify repeated avalanches in the ongoing local field potential (LFP) measured with high-density microelectrode arrays in the cortex of awake nonhuman primates and in acute cortex slices from young and adult rats. We studied extracellular unit firing in vivo and intracellular responses of pyramidal neurons in vitro. We found that single neurons participate selectively in specific LFP-based avalanche patterns. Furthermore, we show in vitro that manipulating the balance of excitation and inhibition abolishes this selectivity. Our results support the view that avalanches represent the selective, scale-invariant formation of neuronal groups in line with the idea of Hebbian cell assemblies underlying cortical information processing. |
| 关键词 | nonhuman primate rat prefrontal cortex primary motor cortex high-density microelectrode array local field potential whole-cell patch recording cell assemblies |
| DOI | 10.3389/fncir.2020.620052 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Division of the Intramural Research Program (DIRP) of the National Institute of Mental Health (NIMH)[ZIAMH002797] |
| 项目资助者 | Division of the Intramural Research Program (DIRP) of the National Institute of Mental Health (NIMH) |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| WOS记录号 | WOS:000614749200001 |
| 出版者 | FRONTIERS MEDIA SA |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/42859 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Plenz, Dietmar |
| 作者单位 | 1.NIMH, Sect Crit Brain Dynam, NIH, Bethesda, MD 20892 USA 2.Brown Univ, Dept Neurosci, Providence, RI 02912 USA 3.Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 5.Stanford Univ, Dept Neurol, Palo Alto, CA 94304 USA |
| 推荐引用方式 GB/T 7714 | Bellay, Timothy,Shew, Woodrow L.,Yu, Shan,et al. Selective Participation of Single Cortical Neurons in Neuronal Avalanches[J]. FRONTIERS IN NEURAL CIRCUITS,2021,14:18. |
| APA | Bellay, Timothy,Shew, Woodrow L.,Yu, Shan,Falco-Walter, Jessica J.,&Plenz, Dietmar.(2021).Selective Participation of Single Cortical Neurons in Neuronal Avalanches.FRONTIERS IN NEURAL CIRCUITS,14,18. |
| MLA | Bellay, Timothy,et al."Selective Participation of Single Cortical Neurons in Neuronal Avalanches".FRONTIERS IN NEURAL CIRCUITS 14(2021):18. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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