High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy

doi:10.1016/j.ijrobp.2020.09.046

	High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy
	Cao, Xu 1,2; Allu, Srinivasa Rao 3,4; Jiang, Shudong 1,5; Gunn, Jason R.1; Yao, Cuiping 1,6; Xin, Jing 1,6; Bruza, Petr 1; Gladstone, David J.1,5,7; Jarvis, Lesley A.5,7; Tian, Jie 2,8; Swartz, Harold M.9; Vinogradov, Sergei A.3; Pogue, Brian W.1,5
发表期刊	INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
ISSN	0360-3016
	2021-02-01
卷号	109 期号:2 页码:603-613
通讯作者	Pogue, Brian W.(brian.w.pogue@dartmouth.edu)
摘要	Purpose: The extreme microscopic heterogeneity of tumors makes it difficult to characterize tumor hypoxia. We evaluated how changes in the spatial resolution of oxygen imaging could alter measures of tumor hypoxia and their correlation to radiation therapy response. Methods and Materials: Cherenkov-Excited Luminescence Imaging in combination with an oxygen probe, Oxyphor PtG4 was used to directly image tumor pO(2) distributions with 0.2 mm spatial resolution at the time of radiation delivery. These pO(2) images were analyzed with variations of reduced spatial resolution from 0.2 mm to 5 mm, to investigate the influence of how reduced imaging spatial resolution would affect the observed tumor hypoxia. As an in vivo validation test, mice bearing tumor xenografts were imaged for hypoxic fraction and median pO(2) to examine the predictive link with tumor response to radiation therapy, while accounting for spatial resolution. Results: In transitioning from voxel sizes of 200 mu m to 3 mm, the median pO(2) values increased by a few mm Hg, and the hypoxic fraction decreased by more than 50%. When looking at radiation-responsive tumors, the median pO(2) values changed just a few mm Hg as a result of treatment, and the hypoxic fractions changed by as much as 50%. This latter change, however, could only be seen when sampling was performed with high spatial resolution. Median pO(2) or similar quantities obtained from low resolution measurements are commonly used in clinical practice, however these parameters are much less sensitive to changes in the tumor microenvironment than the tumor hypoxic fraction obtained from high-resolution oxygen images. Conclusions: This study supports the hypothesis that for adequate measurements of the tumor response to radiation therapy, oxygen imaging with high spatial resolution is required to accurately characterize the hypoxic fraction. (C) 2020 Elsevier Inc. All rights reserved.
DOI	10.1016/j.ijrobp.2020.09.046
关键词[WOS]	HYPERBARIC-OXYGEN ; NECK-CANCER ; PET ; RADIOTHERAPY ; HEAD ; IMPACT ; PHOSPHORESCENCE ; OPPORTUNITIES ; ARABINOSIDE ; MICROPET
收录类别	SCI
语种	英语
资助项目	National Institutes of Health[R01 EB024498] ; National Institutes of Health[U24 EB028941] ; National Institutes of Health[R21 EB027397] ; [P30 CA023108]
项目资助者	National Institutes of Health
WOS研究方向	Oncology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Oncology ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000607368300034
出版者	ELSEVIER SCIENCE INC
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/42901
专题	中国科学院分子影像重点实验室
通讯作者	Pogue, Brian W.
作者单位	1.Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA 2.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol Neuroimaging, Minist Educ, Xian, Shaanxi, Peoples R China 3.Univ Penn, Dept Biochem & Biophys, Perelman Sch Med, Philadelphia, PA 19104 USA 4.Univ Penn, Dept Chem, Sch Arts & Sci, Philadelphia, PA 19104 USA 5.Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Lebanon, NH 03766 USA 6.Xi An Jiao Tong Univ, Inst Biomed Analyt Technol & Instrumentat, Sch Life Sci & Technol, Key Lab Biomed Informat Engn,Minist Educ, Xian, Shaanxi, Peoples R China 7.Dartmouth Coll, Geisel Sch Med, Dept Med, Hanover, NH USA 8.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 9.Dartmouth Coll, Geisel Sch Med, Dept Radiol, Hanover, NH USA
推荐引用方式 GB/T 7714	Cao, Xu,Allu, Srinivasa Rao,Jiang, Shudong,et al. High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2021,109(2):603-613.
APA	Cao, Xu.,Allu, Srinivasa Rao.,Jiang, Shudong.,Gunn, Jason R..,Yao, Cuiping.,...&Pogue, Brian W..(2021).High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy.INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,109(2),603-613.
MLA	Cao, Xu,et al."High-Resolution pO(2) Imaging Improves Quantification of the Hypoxic Fraction in Tumors During Radiation Therapy".INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 109.2(2021):603-613.