Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics

doi:10.1021/acs.bioconjchem.0c00594

	Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics
	Jin, Yushen 1,2; Tang, Chu 3; Tian, Jie 4; Shao, Bing 1,2
发表期刊	BIOCONJUGATE CHEMISTRY
ISSN	1043-1802
	2021-01-20
卷号	32 期号:1 页码:161-171
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Shao, Bing(shaobingch@sina.com)
摘要	Early identification and treatment of breast cancer is very important for breast conserving therapy and to improve the prognosis and survival rates of patients. Multifunctional nanotheranostic agents are of particular importance in the field of precise nanomedicine, since they can augment the visualization and treatment of cancer. We developed a novel Bi2S3 nanoparticle coated with a hyaluronic acid (HA)-modified tantalum oxide (TaOx) nanoshell (Bi2S3@TaOx-HA). The as-prepared core/shell nanoparticles exhibited a high BO, nanoparticle loading efficiency of (67 wt %). The TaOx nanoshell exhibited excellent biocompatibility and computed tomography imaging capacity, and the Bi2S3 nanoparticles exhibited an excellent photothermal transducing performance and computed tomography (CT) and photoacoustic imaging capacity. As a result of these merits, the Bi2S3@TaOx core-shell nanoparticles can act as a theranostic agent for CT/photoacoustically monitored enhanced photothermal therapy. These findings will evoke new interest in future cancer therapeutic strategies based on biocompatible functional nanomaterials.
DOI	10.1021/acs.bioconjchem.0c00594
关键词[WOS]	PHOTOTHERMAL THERAPY ; DRUG-RELEASE ; NANOPARTICLES ; OXIDE ; CHEMOTHERAPY ; AGENTS
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2019YFC1604600] ; National Natural Science Foundation of China[82072098] ; National Natural Science Foundation of China[81701771]
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
WOS记录号	WOS:000612551500017
出版者	AMER CHEMICAL SOC
七大方向——子方向分类	其他
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/43244
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Shao, Bing
作者单位	1.Beijing Ctr Dis Prevent Med Res, Cent Res Lab, Beijing 100013, Peoples R China 2.Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China 3.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian 710126, Shaanxi, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Jin, Yushen,Tang, Chu,Tian, Jie,et al. Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics[J]. BIOCONJUGATE CHEMISTRY,2021,32(1):161-171.
APA	Jin, Yushen,Tang, Chu,Tian, Jie,&Shao, Bing.(2021).Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics.BIOCONJUGATE CHEMISTRY,32(1),161-171.
MLA	Jin, Yushen,et al."Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics".BIOCONJUGATE CHEMISTRY 32.1(2021):161-171.