Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo

doi:10.1007/s12274-020-3246-2

	Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo
	Zhang, Xianghan 1; Zhao, Sumei 1; Gao, Zhiqing 1; Zhou, Jialin 1; Xia, Yuqiong 1; Tian, Jie 1,2; Shi, Changhong 3; Wang, Zhongliang 1
发表期刊	NANO RESEARCH
ISSN	1998-0124
	2021-02-27
页码	9
通讯作者	Tian, Jie(tian@ieee.org) ; Shi, Changhong(changhong@fmmu.edu.cn) ; Wang, Zhongliang(wangzl@xidian.edu.cn)
摘要	Cancer phototheranostics involving optical imaging-guided photodynamic therapy (PDT) and photothermal therapy (PIT) is a localized noninvasive approach in treating cancer. Mitochondria-targeted near-infrared (NIR) cyanines are excellent therapeutic photosensitizers of cancer. However, most mitochondria-targeted cyanines exist in the form of hydrophobic structures, which in vivo may cause cyanine aggregation during blood circulation, resulting in poor biocompatibility and limited therapeutic efficacy. Therefore, we developed a trade-off strategy by encapsulating mitochondria-targeted cyanines into liposomal bilayers (CyBI7-LPs), which balanced hydrophilicity that favored blood circulation and hydrophobicity that enhanced mitochondria tumor targeting. Moreover, CyBI7-LPs greatly minimized photobleaching of cyanine as self-generated reactive oxygen species (ROS) could rapidly escape from the liposomal bilayer, affording enhanced PTT/PDT efficacy. Bioorthogonal-mediated targeting strategy was further employed to improve uptake of tumor cells by modifying the liposomal surface to generate CyB17-LPB. The CyBI7-LPB probe produced a tumor-to-background ratio (TBR) of approximately 6.4 at 24 HPI. Guiding by highly sensitive imaging resulted in excellent anti-tumor therapy outcomes using CyBI7-LPB due to the enhanced photothermal and photodynamic effects. This proposed liposomal nanoplatform exhibited a simple and robust approach as an imaging-guided synergistic anti-tumor therapeutic strategy.
关键词	cancer phototheranostics NIR cyanine liposome mitochondria-targeted phototherapy
DOI	10.1007/s12274-020-3246-2
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFC1309100] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671753] ; National Natural Science Foundation of China[91959124] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[21804104] ; Natural Science Foundation of Shaanxi Province of China[2020PT-020] ; Key Research and Development Program of Shaanxi Province[2019NY-085] ; Natural Science Basic Research Program of Shaanxi Province of China[2019JQ-139] ; Natural Science Basic Research Program of Shaanxi Province of China[2019JQ-662] ; Natural Science Basic Research Program of Shaanxi Province of China[2018JM2041] ; Fundamental Research Funds for the Central Universities[JB191211] ; Fundamental Research Funds for the Central Universities[JB191207] ; Fundamental Research Funds for the Central Universities[JB191208] ; Open Project Program of the State Key Laboratory of Cancer Biology (Fourth Military Medical University)[CBSKL2019ZDKF06]
项目资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Shaanxi Province of China ; Key Research and Development Program of Shaanxi Province ; Natural Science Basic Research Program of Shaanxi Province of China ; Fundamental Research Funds for the Central Universities ; Open Project Program of the State Key Laboratory of Cancer Biology (Fourth Military Medical University)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000622225700001
出版者	TSINGHUA UNIV PRESS
七大方向——子方向分类	其他
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/43325
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Shi, Changhong; Wang, Zhongliang
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuroimaging, Xian 710026, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Fourth Mil Med Univ, Lab Anim Ctr, Xian 710032, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Zhang, Xianghan,Zhao, Sumei,Gao, Zhiqing,et al. Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo[J]. NANO RESEARCH,2021:9.
APA	Zhang, Xianghan.,Zhao, Sumei.,Gao, Zhiqing.,Zhou, Jialin.,Xia, Yuqiong.,...&Wang, Zhongliang.(2021).Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo.NANO RESEARCH,9.
MLA	Zhang, Xianghan,et al."Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced anti-tumor phototherapy in vivo".NANO RESEARCH (2021):9.