CASIA OpenIR  > 中国科学院分子影像重点实验室
Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging
Chen, Hao1; Shou, Kangquan2,3; Chen, Si2,3; Qu, Chunrong1; Wang, Zhiming1; Jiang, Lei2,3; Zhu, Mark2,3; Ding, Bingbing2,3; Qian, Kun2,3; Ji, Aiyan1; Lou, Hongyue1; Tong, Ling4,5; Hsu, Alexander2,3; Wang, Yuebing2,3; Felsher, Dean W.4,5; Hu, Zhenhua6; Tian, Jie6; Cheng, Zhen2,3
Source PublicationADVANCED MATERIALS
ISSN0935-9648
2021-03-12
Pages13
Corresponding AuthorHu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Cheng, Zhen(zcheng@stanford.edu)
AbstractDevelopment of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes in the second near-infrared window (NIR-II, 1000-1700 nm) show high promise because of their exceptional high detection sensitivity, resolution, and deep imaging depth. Here, a sharp pH-sensitive self-assembling cyclopeptide-dye, SIMM1000, as a smart nanoprobe for NIR-II imaging of diseases in living animals, is reported. This small molecule assembled nanoprobe exhibits smart properties by responding to a sharp decrease of pH in the tumor microenvironment (pH 7.0 to 6.8), aggregating from small nanoprobe (80 nm at pH 7.0) into large nanoparticles (>500 nm at pH 6.8) with approximate to 20-30 times enhanced fluorescence compared with the non-self-assembled CH-4T. It yields micrometer-scale resolution in blood vessel imaging and high contrast and resolution in bone and tumor imaging in mice. Because of its self-aggregation in acidic tumor microenvironments in situ, SIMM1000 exhibits high tumor accumulation and extremely long tumor retention (>19 days), while being excretable from normal tissues and safe. This smart self-assembling small molecule strategy can shift the paradigm of designing new nanomaterials for molecular imaging and drug development.
Keywordfluorescence‐ imaging‐ guided tumor surgery NIR‐ II fluorescence imaging pH‐ responsive materials self‐ assembly tumor imaging
DOI10.1002/adma.202006902
Indexed BySCI
Language英语
Funding ProjectOffice of Science (BER), U.S. Department of Energy[DE-SC0008397] ; Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD)[U54 CA151459] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[61622117] ; National Natural Science Foundation of China[82071976] ; Shanghai Pujiang Program[19PJ1411100] ; Shanghai Municipal Science and Technology Major Project
Funding OrganizationOffice of Science (BER), U.S. Department of Energy ; Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD) ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Shanghai Pujiang Program ; Shanghai Municipal Science and Technology Major Project
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000627811500001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/43328
Collection中国科学院分子影像重点实验室
Corresponding AuthorHu, Zhenhua; Tian, Jie; Cheng, Zhen
Affiliation1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Mol Imaging Res, Shanghai 201203, Peoples R China
2.Stanford Univ, Canary Ctr Stanford Canc Early Detect, BioX Program, Mol Imaging Program Stanford MIPS, Stanford, CA 94305 USA
3.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Dept Radiol, Stanford, CA 94305 USA
4.Stanford Univ, Sch Med, Div Oncol, Dept Med, Stanford, CA 94305 USA
5.Stanford Univ, Sch Med, Div Oncol, Dept Pathol, Stanford, CA 94305 USA
6.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging, CAS Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Chen, Hao,Shou, Kangquan,Chen, Si,et al. Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging[J]. ADVANCED MATERIALS,2021:13.
APA Chen, Hao.,Shou, Kangquan.,Chen, Si.,Qu, Chunrong.,Wang, Zhiming.,...&Cheng, Zhen.(2021).Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging.ADVANCED MATERIALS,13.
MLA Chen, Hao,et al."Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging".ADVANCED MATERIALS (2021):13.
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