Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging

doi:10.1002/adma.202006902

	Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging
	Chen, Hao 1; Shou, Kangquan 2,3; Chen, Si 2,3; Qu, Chunrong 1; Wang, Zhiming 1; Jiang, Lei 2,3; Zhu, Mark 2,3; Ding, Bingbing 2,3; Qian, Kun 2,3; Ji, Aiyan 1; Lou, Hongyue 1; Tong, Ling 4,5; Hsu, Alexander 2,3; Wang, Yuebing 2,3; Felsher, Dean W.4,5; Hu, Zhenhua6 ; Tian, Jie 6; Cheng, Zhen 2,3
发表期刊	ADVANCED MATERIALS
ISSN	0935-9648
	2021-03-12
页码	13
通讯作者	Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Cheng, Zhen(zcheng@stanford.edu)
摘要	Development of novel nanomaterials for disease theranostics represents an important direction in chemistry and precision medicine. Fluorescent molecular probes in the second near-infrared window (NIR-II, 1000-1700 nm) show high promise because of their exceptional high detection sensitivity, resolution, and deep imaging depth. Here, a sharp pH-sensitive self-assembling cyclopeptide-dye, SIMM1000, as a smart nanoprobe for NIR-II imaging of diseases in living animals, is reported. This small molecule assembled nanoprobe exhibits smart properties by responding to a sharp decrease of pH in the tumor microenvironment (pH 7.0 to 6.8), aggregating from small nanoprobe (80 nm at pH 7.0) into large nanoparticles (>500 nm at pH 6.8) with approximate to 20-30 times enhanced fluorescence compared with the non-self-assembled CH-4T. It yields micrometer-scale resolution in blood vessel imaging and high contrast and resolution in bone and tumor imaging in mice. Because of its self-aggregation in acidic tumor microenvironments in situ, SIMM1000 exhibits high tumor accumulation and extremely long tumor retention (>19 days), while being excretable from normal tissues and safe. This smart self-assembling small molecule strategy can shift the paradigm of designing new nanomaterials for molecular imaging and drug development.
关键词	fluorescence‐ imaging‐ guided tumor surgery NIR‐ II fluorescence imaging pH‐ responsive materials self‐ assembly tumor imaging
DOI	10.1002/adma.202006902
收录类别	SCI
语种	英语
资助项目	Office of Science (BER), U.S. Department of Energy[DE-SC0008397] ; Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD)[U54 CA151459] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[61622117] ; National Natural Science Foundation of China[82071976] ; Shanghai Pujiang Program[19PJ1411100] ; Shanghai Municipal Science and Technology Major Project
项目资助者	Office of Science (BER), U.S. Department of Energy ; Center for Cancer Nanotechnology Excellence for Translational Diagnostics (CCNE-TD) ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Shanghai Pujiang Program ; Shanghai Municipal Science and Technology Major Project
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000627811500001
出版者	WILEY-V C H VERLAG GMBH
七大方向——子方向分类	其他
引用统计	被引频次：52[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/43328
专题	中国科学院分子影像重点实验室
通讯作者	Hu, Zhenhua; Tian, Jie; Cheng, Zhen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Mol Imaging Res, Shanghai 201203, Peoples R China 2.Stanford Univ, Canary Ctr Stanford Canc Early Detect, BioX Program, Mol Imaging Program Stanford MIPS, Stanford, CA 94305 USA 3.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Dept Radiol, Stanford, CA 94305 USA 4.Stanford Univ, Sch Med, Div Oncol, Dept Med, Stanford, CA 94305 USA 5.Stanford Univ, Sch Med, Div Oncol, Dept Pathol, Stanford, CA 94305 USA 6.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging, CAS Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Chen, Hao,Shou, Kangquan,Chen, Si,et al. Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging[J]. ADVANCED MATERIALS,2021:13.
APA	Chen, Hao.,Shou, Kangquan.,Chen, Si.,Qu, Chunrong.,Wang, Zhiming.,...&Cheng, Zhen.(2021).Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging.ADVANCED MATERIALS,13.
MLA	Chen, Hao,et al."Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging".ADVANCED MATERIALS (2021):13.