Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma | |
Zhang, Weiqi1,2; Hu, Zhenhua2,3 ; Tian, Jie2,3,4,5; Fang, Chihua1
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| Source Publication | ANNALS OF TRANSLATIONAL MEDICINE
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| ISSN | 2305-5839 |
| 2021 | |
| Volume | 9Issue:2Pages:15 |
| Corresponding Author | Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Tian, Jie(tian@ieee.org) ; Fang, Chihua(fangch_dr@163.com) |
| Abstract | Hepatectomy is a main therapeutic strategy for hepatocellular carcinoma (HCC), which requires removal of primary and disseminated tumors and maximum preservation of normal liver tissue. However, in a clinical operation, it is difficult to recognize the tumor tissue and its boundary with the naked eye and palpation, which often leads to insufficient or excessive resection. Near-infrared fluorescence (NIRF) imaging, a non-invasive, real-time, low-cost, and highly sensitive imaging technique has been extensively studied in surgical navigation. With the development of fluorescence imaging system and fluorescent probe, intraoperative tumor detection and margin definition can be achieved, making the operation more accurate. Advances in fluorescence imaging of HCC in the NIR region have focused on the traditional first NIR window (NIR-I, 700-900 nm), and have recently been extended to the second NIR window (NIR-II, 1,000- 1,700 nm). Compared with NIR-I imaging, fluorescence imaging in the NIR-II exhibits great advantages, including higher spatial resolution, deeper penetration depth, and lower optical absorption and scattering from biological substrates with minimal tissue autofluorescence. There is no doubt that developing novel NIRF probes for in vivo imaging of HCC has high significance and direct impact on the field of liver surgery. In this article, the development of various NIRF probes for fluorescence image guided HCC hepatectomy is reviewed, and current challenges and potential opportunities of these imaging probes are discussed. |
| Keyword | Near-infrared fluorescence imaging (NIRF imaging) fluorescent probe hepatectomy hepatocellular carcinoma (HCC) NIR-I NIR-II |
| DOI | 10.21037/atm-20-5341 |
| WOS Keyword | CLINICAL-PRACTICE GUIDELINES ; INDOCYANINE-GREEN ; IN-VIVO ; PHOTOACOUSTIC TOMOGRAPHY ; NAVIGATION SYSTEM ; GUIDED SURGERY ; LIVER-TUMORS ; MANAGEMENT ; RESECTION ; LIGHT |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2016YFC0106500] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[81627805] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[81671759] ; NSFC-GD Union Foundation, China[U1401254] ; National High Technology Research and Development Program of China (863 program)[2006AA02Z346] ; National High Technology Research and Development Program of China (863 program)[2012AA021105] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; innovative research team of high-level local universities in Shanghai |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; NSFC-GD Union Foundation, China ; National High Technology Research and Development Program of China (863 program) ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Nova Program ; innovative research team of high-level local universities in Shanghai |
| WOS Research Area | Oncology ; Research & Experimental Medicine |
| WOS Subject | Oncology ; Medicine, Research & Experimental |
| WOS ID | WOS:000617883200023 |
| Publisher | AME PUBL CO |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/43357 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Hu, Zhenhua; Tian, Jie; Fang, Chihua |
| Affiliation | 1.Southern Med Univ, Guangdong Prov Clin & Engn Ctr Digital Med, Zhujiang Hosp, Dept Hepatobiliary Surg 1, Guangzhou, Peoples R China 2.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging, CAS Key Lab Mol Imaging,Inst Automat, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China 5.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China |
| First Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Automation, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Zhang, Weiqi,Hu, Zhenhua,Tian, Jie,et al. A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9(2):15. |
| APA | Zhang, Weiqi,Hu, Zhenhua,Tian, Jie,&Fang, Chihua.(2021).A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma.ANNALS OF TRANSLATIONAL MEDICINE,9(2),15. |
| MLA | Zhang, Weiqi,et al."A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma".ANNALS OF TRANSLATIONAL MEDICINE 9.2(2021):15. |
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