Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility

doi:10.1016/j.neuroscience.2021.02.031

	Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility
	He, Yini 1,2; Li, Kaixin 2,3; Li, Jin2 ; Wang, Jiaojian 1; Cheng, Nanhua 4; Xiao, Jing 4; Jiang, Tianzi1,2,5,6,7
发表期刊	NEUROSCIENCE
ISSN	0306-4522
	2021-05-01
卷号	461 页码:36-43
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
摘要	As a textbook manifestation of an aggressive attitude, hostility can pose a serious threat to both an individual?s life and the security of society at large. Past evidence suggests that some anxiety-related traits may be more prone to giving rise to hostility. However, many aspects of hostility, such as, determining the susceptible temperament for hostility, the neural basis of hostility, and the underlying mechanisms through which having a susceptible temperament generates hostility in a healthy brain, remain unclear. In this study, we sought to delve into these questions by assessing temperament and brain white matter integrity using self-report questionnaires and diffusion tensor imaging in a sizable sample of healthy adults (n = 357). First, we investigated the relationship between hostility and the four temperaments of the Cloninger model. Then, we investigated which white matter tracts were significantly correlated with hostility using a whole-brain analysis. Finally, we used a mediation analysis to explore the tripartite relationship between vulnerability temperament, the fractional anisotropy (FA) value of the white matter, and hostility. Our results suggest that a harm avoidance temperament may be susceptible to hostility and that the cingulum may be a key white matter region responsible for hostility. Based on these results, we developed a temperament-brain-attitude pathway showing how harm avoidance temperament could affect the brain and ultimately lead to hostility. ? 2021 Published by Elsevier Ltd on behalf of IBRO.
关键词	hostility white matter cingulum temperament harm avoidance mediation analysis
DOI	10.1016/j.neuroscience.2021.02.031
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFB1002502] ; National Key Research and Development Program of China[2017YFA0105203] ; Natural Science Foundation of China[91432302] ; Natural Science Foundation of China[31620103905] ; Natural Science Foundation of China[81501179] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJSSWSMC019] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z161100000216152] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z161100000216139] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z171100000117002] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z181100001518003] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z181100001518004] ; Guangdong Pearl River Talents Plan[2016ZT06S220] ; Youth Innovation Promotion Association ; Beijing Advanced Discipline Fund
项目资助者	National Key Research and Development Program of China ; Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission ; Guangdong Pearl River Talents Plan ; Youth Innovation Promotion Association ; Beijing Advanced Discipline Fund
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000639337600004
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/44276
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Jiang, Tianzi
作者单位	1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 3.Harbin Univ Sci & Technol, Sch Mech & Power Engn, Harbin 150080, Peoples R China 4.Capital Normal Univ, Sch Psychol, Beijing Key Lab Learning & Cognit, Beijing 100048, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	He, Yini,Li, Kaixin,Li, Jin,et al. Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility[J]. NEUROSCIENCE,2021,461:36-43.
APA	He, Yini.,Li, Kaixin.,Li, Jin.,Wang, Jiaojian.,Cheng, Nanhua.,...&Jiang, Tianzi.(2021).Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility.NEUROSCIENCE,461,36-43.
MLA	He, Yini,et al."Cingulum White Matter Integrity as a Mediator Between Harm Avoidance and Hostility".NEUROSCIENCE 461(2021):36-43.