CASIA OpenIR  > 脑网络组研究
Temporal-Adaptive Graph Convolutional Network for Automated Identification of Major Depressive Disorder Using Resting-State fMRI
Dongren Yao1,2,3; Jing Sui1,2; Erkun Yang3; Pew-Thian Yap3; Dinggang Shen3; Mingxia Liu3
2020
Conference NameInternational Workshop on Machine Learning in Medical Imaging
Conference Date2020/10/4
Conference PlaceLima
Abstract

Extensive studies focus on analyzing human brain functional connectivity from a network perspective, in which each network contains complex graph structures. Based on resting-state functional MRI (rs-fMRI) data, graph convolutional networks (GCNs) enable comprehensive mapping of brain functional connectivity (FC) patterns to depict brain activities. However, existing studies usually characterize static properties of the FC patterns, ignoring the time-varying dynamic information. In addition, previous GCN methods generally use fixed group-level (e.g., patients or controls) representation of FC networks, and thus, cannot capture subject-level FC specificity. To this end, we propose a Temporal-Adaptive GCN (TAGCN) framework that can not only take advantage of both spatial and temporal information using resting-state FC patterns and time-series but also explicitly characterize subject-level specificity of FC patterns. Specifically, we first segment each ROI-based time-series into multiple overlapping windows, then employ an adaptive GCN to mine topological information. We further model the temporal patterns for each ROI along time to learn the periodic brain status changes. Experimental results on 533 major depressive disorder (MDD) and health control (HC) subjects demonstrate that the proposed TAGCN outperforms several state-of-the-art methods in MDD vs. HC classification, and also can be used to capture dynamic FC alterations and learn valid graph representations.

Indexed ByEI
Sub direction classification人工智能+医疗
Document Type会议论文
Identifierhttp://ir.ia.ac.cn/handle/173211/44818
Collection脑网络组研究
Corresponding AuthorJing Sui; Dinggang Shen; Mingxia Liu
Affiliation1.Brainentome Center and National Laboratory of Pattern RecognitionInstitute of Automation, Chinese Academy of Sciences
2.University of Chinese Academy of Sciences
3.Department of Radiology and BRICUniversity of North Carolina at Chapel Hill
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Dongren Yao,Jing Sui,Erkun Yang,et al. Temporal-Adaptive Graph Convolutional Network for Automated Identification of Major Depressive Disorder Using Resting-State fMRI[C],2020.
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