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Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery
Shi,Xiaojing1,2; Cao,Caiguang1,2; Zhang,Zeyu1,3; Tian,Jie1,2,3; Hu,Zhenhua1,2
Source PublicationJournal of Nanobiotechnology
2021-07-16
Volume19Issue:1Pages:14
Abstract

AbstractCerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limited by weak optical signal and restricted tissue penetration depth. Various fluorescent probes have been combined with radiopharmaceuticals for improved imaging performances. However, as most of these probes only interact with Cerenkov luminescence (CL), the low photon fluence of CL greatly restricted it’s interaction with fluorescent probes for in vivo imaging. Therefore, it is important to develop probes that can effectively convert energy beyond CL such as β and γ to the low energy optical signals. In this study, a Eu3+ doped gadolinium oxide (Gd2O3:Eu) was synthesized and combined with radiopharmaceuticals to achieve a red-shifted optical spectrum with less tissue scattering and enhanced optical signal intensity in this study. The interaction between Gd2O3:Eu and radiopharmaceutical were investigated using 18F-fluorodeoxyglucose (18F-FDG). The ex vivo optical signal intensity of the mixture of Gd2O3:Eu and 18F-FDG reached 369 times as high as that of CLI using 18F-FDG alone. To achieve improved biocompatibility, the Gd2O3:Eu nanoparticles were then modified with polyvinyl alcohol (PVA), and the resulted nanoprobe PVA modified Gd2O3:Eu (Gd2O3:Eu@PVA) was applied in intraoperative tumor imaging. Compared with 18F-FDG alone, intraoperative administration of Gd2O3:Eu@PVA and 18F-FDG combination achieved a much higher tumor-to-normal tissue ratio (TNR, 10.24?±?2.24 vs. 1.87?±?0.73, P?=?0.0030). The use of Gd2O3:Eu@PVA and 18F-FDG also assisted intraoperative detection of tumors that were omitted by preoperative positron emission tomography (PET) imaging. Further experiment of image-guided surgery demonstrated feasibility of image-guided tumor resection using Gd2O3:Eu@PVA and 18F-FDG. In summary, Gd2O3:Eu can achieve significantly optimized imaging property when combined with 18F-FDG in intraoperative tumor imaging and image-guided tumor resection surgery. It is expected that the development of the Gd2O3:Eu nanoparticle will promote investigation and application of novel nanoparticles that can interact with radiopharmaceuticals for improved imaging properties. This work highlighted the impact of the nanoprobe that can be excited by radiopharmaceuticals emitting CL, β, and γ radiation for precisely imaging of tumor and intraoperatively guide tumor resection.

KeywordRadiopharmaceuticals Gd2O3:Eu Cerenkov luminescence imaging Optical imaging Image-guided surgery
DOI10.1186/s12951-021-00920-6
WOS KeywordLUMINESCENCE ; RADIATION ; THERAPY
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[81227901] ; Beijing Natural Science Foundation[JQ19027] ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project[HLHPTP201703]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China (NSFC) ; Beijing Natural Science Foundation ; innovative research team of high-level local universities in Shanghai ; Zhuhai High-level Health Personnel Team Project
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDBMC:10.1186/s12951-021-00920-6
PublisherBioMed Central
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/45088
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian,Jie; Hu,Zhenhua
Affiliation1.Chinese Academy of Sciences; CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation
2.University of Chinese Academy of Sciences; School of Artificial Intelligence
3.Beihang University; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine
Recommended Citation
GB/T 7714
Shi,Xiaojing,Cao,Caiguang,Zhang,Zeyu,et al. Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery[J]. Journal of Nanobiotechnology,2021,19(1):14.
APA Shi,Xiaojing,Cao,Caiguang,Zhang,Zeyu,Tian,Jie,&Hu,Zhenhua.(2021).Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery.Journal of Nanobiotechnology,19(1),14.
MLA Shi,Xiaojing,et al."Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery".Journal of Nanobiotechnology 19.1(2021):14.
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