Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows | |
Yang, Junying1,2,6; He, Shuqing3,7,8; Hu, Zhenhua2,5![]() ![]() ![]() | |
发表期刊 | NANO TODAY
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ISSN | 1748-0132 |
2021-06-01 | |
卷号 | 38页码:11 |
通讯作者 | Hu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Cheng, Zhen(zcheng@stanford.edu) ; Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn) |
摘要 | In vivo fluorescence imaging in the near-infrared II window (NIR-II, 1000 & ndash;1700 nm) has great improvements in imaging quality compared with the visible (400 & ndash;700 nm) and the NIR-I (700 & ndash;900 nm) window due to the low autofluorescence and the reduced scattering. To date, a variety of NIR-II fluorophores have been synthesized and applied in vivo imaging and disease diagnosis. Multifunction is believed as one of the developing trends. In this study, we report a liposome-coated lanthanide nanoparticle, named as NPs@Lips, which can emit three-wavelengths fluorescence (1000 & ndash;1100 nm (NIR-II), 1300 & ndash;1350 nm (NIR-IIa), 1500 & ndash;1700 nm (NIR-IIb) simultaneously under an 808 nm laser excitation. The imaging results demonstrated that the images in longer wavelengths provided a higher resolution and enhanced signal-to-noise (S/N) ratio than the ones in shorter wavelengths. Then, the NPs@Lips were studied for in vivo multifunctional biological imaging, including brown adipose tissue imaging, vascular imaging and lymph node localization biopsy. Interestingly, NPs@Lips can accumulate in brown adipose tissue without any targeting molecules, which provided an alternative sensitive and non-radiation method for brown adipose tissue imaging in the field of metabolic disorders. Overall, the NPs@Lips were potential NIR-II probe for multifunctional nanomedicine applications. (c) 2021 Elsevier Ltd. All rights reserved. |
关键词 | NIR-II IIa IIb windows Fluorescence imaging Brown adipose tissue Multifunctional nanoprobe Rare-earth-doped nanoparticle Excretory capacity |
DOI | 10.1016/j.nantod.2021.101120 |
关键词[WOS] | FLUOROPHORES ; NANOPROBES ; SYSTEM ; GREEN |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China (NSFC)[81627805] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[22004087] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2016YFC0106500] ; NSFC-GD Union Foundation[U1401254] ; Chinese Academy of Sciences[GJJSTD20170004] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Shenzhen Science and Technology Innovation Commission[JCYJ20170817094201000] ; Shenzhen Science and Technology Innovation Commission[JCYJ20190809145601651] ; Natural Science Foundation of Top Talent of SZTU[20200202] ; Guangdong Basic and Applied Basic Research Foundation[2019A1515110926] ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project[201604020144] ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project[201704020141] ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703] |
项目资助者 | National Natural Science Foundation of China (NSFC) ; National Key Research and Development Program of China ; NSFC-GD Union Foundation ; Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Nova Program ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Shenzhen Science and Technology Innovation Commission ; Natural Science Foundation of Top Talent of SZTU ; Guangdong Basic and Applied Basic Research Foundation ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project ; Zhuhai High-level Health Personnel Team Project |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
WOS记录号 | WOS:000670255000002 |
出版者 | ELSEVIER SCI LTD |
七大方向——子方向分类 | 医学影像处理与分析 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/45250 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Hu, Zhenhua; Cheng, Zhen; Fang, Chihua; Tian, Jie |
作者单位 | 1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Peoples R China 2.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China 3.Shenzhen Technol Univ, Coll Hlth Sci & Environm Engn, Shenzhen 518118, Peoples R China 4.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Peoples R China 7.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Mol Imaging Program Stanford MIPS, Bio X Program, Stanford, CA 94305 USA 8.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Dept Radiol, Stanford, CA 94305 USA |
第一作者单位 | 中国科学院自动化研究所 |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Yang, Junying,He, Shuqing,Hu, Zhenhua,et al. In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows[J]. NANO TODAY,2021,38:11. |
APA | Yang, Junying.,He, Shuqing.,Hu, Zhenhua.,Zhang, Zeyu.,Cao, Caiguang.,...&Tian, Jie.(2021).In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows.NANO TODAY,38,11. |
MLA | Yang, Junying,et al."In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows".NANO TODAY 38(2021):11. |
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