CASIA OpenIR  > 中国科学院分子影像重点实验室
In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows
Yang, Junying1,2,6; He, Shuqing3,7,8; Hu, Zhenhua2,5; Zhang, Zeyu2; Cao, Caiguang2,5; Cheng, Zhen7,8; Fang, Chihua1,6; Tian, Jie2,4
Source PublicationNANO TODAY
ISSN1748-0132
2021-06-01
Volume38Pages:11
Corresponding AuthorHu, Zhenhua(zhenhua.hu@ia.ac.cn) ; Cheng, Zhen(zcheng@stanford.edu) ; Fang, Chihua(fangch_dr@163.com) ; Tian, Jie(jie.tian@ia.ac.cn)
AbstractIn vivo fluorescence imaging in the near-infrared II window (NIR-II, 1000 & ndash;1700 nm) has great improvements in imaging quality compared with the visible (400 & ndash;700 nm) and the NIR-I (700 & ndash;900 nm) window due to the low autofluorescence and the reduced scattering. To date, a variety of NIR-II fluorophores have been synthesized and applied in vivo imaging and disease diagnosis. Multifunction is believed as one of the developing trends. In this study, we report a liposome-coated lanthanide nanoparticle, named as NPs@Lips, which can emit three-wavelengths fluorescence (1000 & ndash;1100 nm (NIR-II), 1300 & ndash;1350 nm (NIR-IIa), 1500 & ndash;1700 nm (NIR-IIb) simultaneously under an 808 nm laser excitation. The imaging results demonstrated that the images in longer wavelengths provided a higher resolution and enhanced signal-to-noise (S/N) ratio than the ones in shorter wavelengths. Then, the NPs@Lips were studied for in vivo multifunctional biological imaging, including brown adipose tissue imaging, vascular imaging and lymph node localization biopsy. Interestingly, NPs@Lips can accumulate in brown adipose tissue without any targeting molecules, which provided an alternative sensitive and non-radiation method for brown adipose tissue imaging in the field of metabolic disorders. Overall, the NPs@Lips were potential NIR-II probe for multifunctional nanomedicine applications. (c) 2021 Elsevier Ltd. All rights reserved.
KeywordNIR-II IIa IIb windows Fluorescence imaging Brown adipose tissue Multifunctional nanoprobe Rare-earth-doped nanoparticle Excretory capacity
DOI10.1016/j.nantod.2021.101120
WOS KeywordFLUOROPHORES ; NANOPROBES ; SYSTEM ; GREEN
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China (NSFC)[81627805] ; National Natural Science Foundation of China (NSFC)[62027901] ; National Natural Science Foundation of China (NSFC)[81930053] ; National Natural Science Foundation of China (NSFC)[92059207] ; National Natural Science Foundation of China (NSFC)[61622117] ; National Natural Science Foundation of China (NSFC)[81671759] ; National Natural Science Foundation of China (NSFC)[81227901] ; National Natural Science Foundation of China (NSFC)[22004087] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2016YFC0106500] ; NSFC-GD Union Foundation[U1401254] ; Chinese Academy of Sciences[GJJSTD20170004] ; Beijing Natural Science Foundation[JQ19027] ; Beijing Nova Program[Z181100006218046] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[YZ201672] ; Shenzhen Science and Technology Innovation Commission[JCYJ20170817094201000] ; Shenzhen Science and Technology Innovation Commission[JCYJ20190809145601651] ; Natural Science Foundation of Top Talent of SZTU[20200202] ; Guangdong Basic and Applied Basic Research Foundation[2019A1515110926] ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project[201604020144] ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project[201704020141] ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703]
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; National Key Research and Development Program of China ; NSFC-GD Union Foundation ; Chinese Academy of Sciences ; Beijing Natural Science Foundation ; Beijing Nova Program ; Scientific Instrument Developing Project of the Chinese Academy of Sciences ; Shenzhen Science and Technology Innovation Commission ; Natural Science Foundation of Top Talent of SZTU ; Guangdong Basic and Applied Basic Research Foundation ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project ; Zhuhai High-level Health Personnel Team Project
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000670255000002
PublisherELSEVIER SCI LTD
Sub direction classification医学影像处理与分析
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/45250
Collection中国科学院分子影像重点实验室
Corresponding AuthorHu, Zhenhua; Cheng, Zhen; Fang, Chihua; Tian, Jie
Affiliation1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Peoples R China
2.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,Inst Automat, Beijing 100190, Peoples R China
3.Shenzhen Technol Univ, Coll Hlth Sci & Environm Engn, Shenzhen 518118, Peoples R China
4.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Peoples R China
7.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Mol Imaging Program Stanford MIPS, Bio X Program, Stanford, CA 94305 USA
8.Stanford Univ, Canary Ctr Stanford Canc Early Detect, Dept Radiol, Stanford, CA 94305 USA
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yang, Junying,He, Shuqing,Hu, Zhenhua,et al. In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows[J]. NANO TODAY,2021,38:11.
APA Yang, Junying.,He, Shuqing.,Hu, Zhenhua.,Zhang, Zeyu.,Cao, Caiguang.,...&Tian, Jie.(2021).In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows.NANO TODAY,38,11.
MLA Yang, Junying,et al."In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows".NANO TODAY 38(2021):11.
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