CASIA OpenIR  > 中国科学院分子影像重点实验室
Depth-recognizable time-domain fluorescence molecular tomography in reflective geometry
Cheng, Jiaju1; Zhang, Peng2,3; Cai, Chuangjian1; Gao, Yang1; Liu, Jie2; Hui, Hui3; Tian, Jie3,4; Luo, Jianwen1
Source PublicationBIOMEDICAL OPTICS EXPRESS
ISSN2156-7085
2021-07-01
Volume12Issue:7Pages:3806-3818
Corresponding AuthorLuo, Jianwen(luo_jianwen@tsinghua.edu.cn)
AbstractFluorescence molecular tomography (FMT) is a functional imaging modality which is capable of noninvasively detecting in-vivo biological activities on molecular level. It provides quantitatively accurate three-dimensional (3D) distributions of endogenous or exogenous fluorescent biomarkers in thick and highly scattering media such as biological tissues. Therefore, FMT is a vital tool in preclinical oncology research, drug development and other biological research areas [1-5]. Despite its advantages of non-ionizing radiation and low cost, the emerging clinical applications of FMT have been hampered not only by its low spatial resolution caused by the ill-posed nature Conventional fluorescence molecular tomography (FMT) reconstruction requires photons penetrating the whole object, which limits its applications to small animals. However, by utilizing reflective photons, fluorescence distribution near the surface could be reconstructed regardless of the object size, which may extend the applications of FMT to surgical navigation and so on. Therefore, time-domain reflective fluorescence molecular tomography (TD-rFMT) is proposed in this paper. The system excites and detects the emission light from the same angle within a field of view of 5 cm. Because the detected intensities of targets depend strongly on the depth, the reconstruction of targets in deep regions would be evidently affected. Therefore, a fluorescence yield reconstruction method with depth regularization and a weighted separation reconstruction strategy for lifetime are developed to enhance the performance for deep targets. Through simulations and phantom experiments, TD-rFMT is proved capable of reconstructing fluorescence distribution within a 2.5-cm depth with accurate reconstructed yield, lifetime, and target position(s).
DOI10.1364/BOE.430235
WOS KeywordL1 REGULARIZATION ; RECONSTRUCTION METHOD ; MOUSE MODEL
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China (NSFC)[61871022] ; National Natural Science Foundation of China (NSFC)[61871251] ; National Natural Science Foundation of China (NSFC)[61871263] ; National Natural Science Foundation of China (NSFC)[62027901]
Funding OrganizationNational Natural Science Foundation of China (NSFC)
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000671937600005
PublisherOPTICAL SOC AMER
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/45268
Collection中国科学院分子影像重点实验室
Corresponding AuthorLuo, Jianwen
Affiliation1.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
2.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Jiaju,Zhang, Peng,Cai, Chuangjian,et al. Depth-recognizable time-domain fluorescence molecular tomography in reflective geometry[J]. BIOMEDICAL OPTICS EXPRESS,2021,12(7):3806-3818.
APA Cheng, Jiaju.,Zhang, Peng.,Cai, Chuangjian.,Gao, Yang.,Liu, Jie.,...&Luo, Jianwen.(2021).Depth-recognizable time-domain fluorescence molecular tomography in reflective geometry.BIOMEDICAL OPTICS EXPRESS,12(7),3806-3818.
MLA Cheng, Jiaju,et al."Depth-recognizable time-domain fluorescence molecular tomography in reflective geometry".BIOMEDICAL OPTICS EXPRESS 12.7(2021):3806-3818.
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