Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings

doi:10.1117/1.JBO.26.5.050901

	Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings
	Azari, Feredun 1; Kennedy, Gregory 1; Bernstein, Elizabeth 1; Hadjipanayis, Constantinos 2; Vahrmeijer, Alexander L.3; Smith, Barbara L.4; Rosenthal, Eben 5; Sumer, Baran 6; Tian, Jie 7; Henderson, Eric R.8; Lee, Amy 9; Quyen Nguyen 10; Gibbs, Summer L.11; Pogue, Brian W.8,12; Orringer, Daniel A.13; Charalampaki, Cleopatra 14; Martin, Linda W.15; Tanyi, Janos L.1; Lee, Major Kenneth 1; Lee, John Y. K.1; Singhal, Sunil 1
发表期刊	JOURNAL OF BIOMEDICAL OPTICS
ISSN	1083-3668
	2021-05-01
卷号	26 期号:5 页码:22
通讯作者	Singhal, Sunil(sunil.singhal@pennmedicine.upenn.edu)
摘要	Significance: Surgery is often paramount in the management of many solid organ malignancies because optimal resection is a major factor in disease-specific survival. Cancer surgery has multiple challenges including localizing small lesions, ensuring negative surgical margins around a tumor, adequately staging patients by discriminating positive lymph nodes, and identifying potential synchronous cancers. Intraoperative molecular imaging (IMI) is an emerging potential tool proposed to address these issues. IMI is the process of injecting patients with fluorescenttargeted contrast agents that highlight cancer cells prior to surgery. Over the last 5 to 7 years, enormous progress has been achieved in tracer development, near-infrared camera approvals, and clinical trials. Therefore, a second biennial conference was organized at the University of Pennsylvania to gather surgical oncologists, scientists, and experts to discuss new investigative findings in the field. Our review summarizes the discussions from the conference and highlights findings in various clinical and scientific trials. Aim: Recent advances in IMI were presented, and the importance of each clinical trial for surgical oncology was critically assessed. A major focus was to elaborate on the clinical endpoints that were being utilized in IMI trials to advance the respective surgical subspecialties. Approach: Principal investigators presenting at the Perelman School of Medicine Abramson Cancer Center's second clinical trials update on IMI were selected to discuss their clinical trials and endpoints. Results: Multiple phase III, II, and I trials were discussed during the conference. Since the approval of 5-ALA for commercial use in neurosurgical malignancies, multiple tracers and devices have been developed to address common challenges faced by cancer surgeons across numerous specialties. Discussants also presented tracers that are being developed for delineation of normal anatomic structures that can serve as an adjunct during surgical procedures. Conclusions: IMI is increasingly being recognized as an improvement to standard oncologic surgical resections and will likely advance the art of cancer surgery in the coming years. The endpoints in each individual surgical subspecialty are varied depending on how IMI helps each specialty solve their clinical challenges. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.
关键词	intraoperative molecular imaging fluorescence-guided surgery tumor surgery optical biopsy intraoperative visualization molecular imaging
DOI	10.1117/1.JBO.26.5.050901
关键词[WOS]	FLUORESCENCE-GUIDED SURGERY ; BREAST-CANCER ; PANITUMUMAB-IRDYE800CW ; RESECTION ; SGM-101 ; FUTURE ; CEA
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000657333600001
出版者	SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/45326
专题	中国科学院分子影像重点实验室
通讯作者	Singhal, Sunil
作者单位	1.Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA 2.Icahn Sch Med Mt Sinai, New York, NY USA 3.Leiden Univ, Med Ctr, Leiden, Netherlands 4.Harvard Univ, Sch Med, Boston, MA USA 5.Stanford Univ, Sch Med, Stanford, CA USA 6.Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA 7.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 8.Dartmouth Coll, Geisel Sch Med, Hanover, NH USA 9.Univ Washington, Sch Med, Seattle, WA USA 10.Univ Calif San Diego, Sch Med, San Diego, CA USA 11.Oregon Hlth & Sci Univ, Sch Med, Knight Canc Inst, Portland, OR USA 12.Thayer Sch Engn Dartmouth, Hanover, NH USA 13.Univ Michigan, Ann Arbor, MI 48109 USA 14.Cologne Med Ctr, Cologne, Germany 15.Univ Virginia, Sch Med, Charlottesville, VA 22908 USA
推荐引用方式 GB/T 7714	Azari, Feredun,Kennedy, Gregory,Bernstein, Elizabeth,et al. Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings[J]. JOURNAL OF BIOMEDICAL OPTICS,2021,26(5):22.
APA	Azari, Feredun.,Kennedy, Gregory.,Bernstein, Elizabeth.,Hadjipanayis, Constantinos.,Vahrmeijer, Alexander L..,...&Singhal, Sunil.(2021).Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings.JOURNAL OF BIOMEDICAL OPTICS,26(5),22.
MLA	Azari, Feredun,et al."Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings".JOURNAL OF BIOMEDICAL OPTICS 26.5(2021):22.