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Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation
Qi, Jing1,2; Li, Bo-Zhi2; Zhang, Ying3; Pan, Bei4; Gao, Yu-Hong5; Zhan, Hao4; Liu, Yong6,7,8,9; Shao, Yong-Cong10,11; Zhang, Xi1,2
Source PublicationBEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
2021-07-09
Volume409Pages:7
Corresponding AuthorShao, Yong-Cong(beijingshuimian@163.com) ; Zhang, Xi(smrc301@163.com)
AbstractBackground: Sleep deprivation can markedly influence vigilant attention. The nucleus basalis of Meynert (NBM), the main source of cholinergic projections to the cortex, plays an important role in wakefulness maintenance and attention control. However, the involvement of NBM in attentional impairments after total sleep deprivation (TSD) has yet to be established. The purpose of this study is to investigate the alterations in NBM functional connectivity and its association with the attentional performance following TSD. Methods: Thirty healthy adult males were recruited in the study. Participants underwent two resting-state functional magnetic resonance imaging (rs-fMRI) scans, once in rested wakefulness (RW) and once after 36 h of TSD. Seed-based functional connectivity analysis was performed using rs-fMRI data for the left and right NBM. The vigilant attention was measured using a psychomotor vigilance test (PVT). Furthermore, Pearson correlation analysis was conducted to investigate the relationship between altered NBM functional connectivity and changed PVT performance after TSD. Results: Compared to RW, enhanced functional connectivity was observed between right NBM and bilateral thalamus and cingulate cortex, while reduced functional connectivity was observed between left NBM and right superior parietal lobule following TSD. Moreover, altered NBM functional connectivity with the left anterior cingulate cortex was negatively correlated with PVT performance after TSD. Conclusion: Our results suggest that the disrupted NBM-related cholinergic circuit highlights an important role in attentional performance after TSD. The enhanced NBM functional connectivity with the anterior cingulate cortex may act as neural signatures for attentional deficits induced by sleep deprivation.
KeywordSleep deprivation Vigilant attention Nucleus basalis of Meynert Functional connectivity fMRI
DOI10.1016/j.bbr.2021.113321
WOS KeywordNICOTINIC RECEPTORS ; RAT ; VULNERABILITY ; SUBREGIONS ; NEURONS ; MAPS
Indexed BySCI
Language英语
Funding ProjectScience Foundation[AWS16J023] ; Science Foundation[1716312ZT00211101]
Funding OrganizationScience Foundation
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000663072600009
PublisherELSEVIER
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/45341
Collection脑图谱与类脑智能实验室_脑网络组研究
Corresponding AuthorShao, Yong-Cong; Zhang, Xi
Affiliation1.Nankai Univ, Sch Med, Tianjin 300071, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Secondary Med Ctr, Sleep Med Res Ctr, Natl Clin Res Ctr Geriatr Dis,Dept Neurol, Beijing 100853, Peoples R China
3.Gen Hosp Peoples Liberat Army, Eighth Med Ctr, Beijing 100091, Peoples R China
4.PLA, Airforce Med Ctr, Beijing 100142, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Beijing 100853, Peoples R China
6.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
8.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China
9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
10.Beijing Sport Univ, Sch Psychol, Beijing 100084, Peoples R China
11.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Qi, Jing,Li, Bo-Zhi,Zhang, Ying,et al. Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation[J]. BEHAVIOURAL BRAIN RESEARCH,2021,409:7.
APA Qi, Jing.,Li, Bo-Zhi.,Zhang, Ying.,Pan, Bei.,Gao, Yu-Hong.,...&Zhang, Xi.(2021).Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation.BEHAVIOURAL BRAIN RESEARCH,409,7.
MLA Qi, Jing,et al."Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation".BEHAVIOURAL BRAIN RESEARCH 409(2021):7.
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