Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan

doi:10.1093/cercor/bhab059

	Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan
	Ma, Liying 1,2; Tian, Lixia 1; Hu, Tianyu2,3,4 ; Jiang, Tianzi2,3,4,5,6,7,8 ; Zuo, Nianming2,3,4,5
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
	2021-08-01
卷号	31 期号:8 页码:3925-3938
通讯作者	Zuo, Nianming(nmzuo@nlpr.ia.ac.cn)
摘要	Individual variability exists in both brain function and behavioral performance. However, changes in individual variability in brain functional connectivity and capability across adult development and aging have not yet been clearly examined. Based on resting-state functional magnetic resonance imaging data from a large cohort of participants (543 adults, aged 18-88 years), brain functional connectivity was analyzed to characterize the spatial distribution and differences in individual variability across the adult lifespan. Results showed high individual variability in the association cortex over the adult lifespan, whereas individual variability in the primary cortex was comparably lower in the initial stage but increased with age. Individual variability was also negatively correlated with the strength/number of short-, medium-, and long-range functional connections in the brain, with long-range connections playing a more critical role in increasing global individual variability in the aging brain. More importantly, in regard to specific brain regions, individual variability in the motor cortex was significantly correlated with differences in motor capability. Overall, we identified specific patterns of individual variability in brain functional structure during the adult lifespan and demonstrated that functional variability in the brain can reflect behavioral performance. These findings advance our understanding of the underlying principles of the aging brain across the adult lifespan and suggest how to characterize degenerating behavioral capability using imaging biomarkers.
关键词	adult lifespan brain connectivity connection distance functional MRI (fMRI) individual variability (IndVar)
DOI	10.1093/cercor/bhab059
关键词[WOS]	NORMAL HUMAN CORTEX ; AGE-RELATED-CHANGES ; PREFRONTAL CORTEX ; CYTOARCHITECTONIC DEFINITION ; SEX-DIFFERENCES ; WORKING-MEMORY ; GLOBAL SIGNAL ; AREAS 9 ; NETWORKS ; STATE
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[61971420] ; National Natural Science Foundation of China[31620103905] ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission[Z181100001518003] ; Special Projects of Brain Science of the Beijing Municipal Science & Technology Commission[Z161100000216139] ; Special Projects of Brain Science of the Beijing Municipal Science & Technology Commission[Z171100000117002]
项目资助者	National Natural Science Foundation of China ; Beijing Brain Initiative of the Beijing Municipal Science & Technology Commission ; Special Projects of Brain Science of the Beijing Municipal Science & Technology Commission
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000674446400025
出版者	OXFORD UNIV PRESS INC
七大方向——子方向分类	脑网络分析
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/45532
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Zuo, Nianming
作者单位	1.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Beijing 100044, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 5.Chinese Inst Brain Res, Beijing 102206, Peoples R China 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab Neuro Informat, Minist Educ, Chengdu 625014, Peoples R China 8.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Ma, Liying,Tian, Lixia,Hu, Tianyu,et al. Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan[J]. CEREBRAL CORTEX,2021,31(8):3925-3938.
APA	Ma, Liying,Tian, Lixia,Hu, Tianyu,Jiang, Tianzi,&Zuo, Nianming.(2021).Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan.CEREBRAL CORTEX,31(8),3925-3938.
MLA	Ma, Liying,et al."Development of Individual Variability in Brain Functional Connectivity and Capability across the Adult Lifespan".CEREBRAL CORTEX 31.8(2021):3925-3938.