| Ferroptosis in liver disease: new insights into disease mechanisms | |
Wu, Jing1; Wang, Yi2 ; Jiang, Rongtao3; Xue, Ran4; Yin, Xuehong1; Wu, Muchen1; Meng, Qinghua1
| |
| 发表期刊 | CELL DEATH DISCOVERY
 |
| 2021-10-05 | |
| 卷号 | 7期号:1页码:9 |
| 通讯作者 | Wang, Yi(yves.wangy@vip.163.com) ; Meng, Qinghua(meng_qh0805@ccmu.edu.cn) |
| 摘要 | Characterized by excessive iron accumulation and lipid peroxidation, ferroptosis is a novel form of iron-dependent cell death, which is morphologically, genetically, and biochemically distinct from other well-known cell death. In recent years, ferroptosis has been quickly gaining attention in the field of liver diseases, as the liver is predisposed to oxidative injury and generally, excessive iron accumulation is a primary characteristic of most major liver diseases. In the current review, we first delineate three cellular defense mechanisms against ferroptosis (GPx4 in the mitochondria and cytosol, FSP1 on plasma membrane, and DHODH in mitochondria), along with four canonical modulators of ferroptosis (system Xc(-), nuclear factor erythroid 2-related factor 2, p53, and GTP cyclohydrolase-1). Next, we review recent progress of ferroptosis studies delineating molecular mechanisms underlying the pathophysiology of several common liver diseases including ischemia/reperfusion-related injury (IRI), nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), hemochromatosis (HH), drug-induced liver injury (DILI), and hepatocellular carcinoma (HCC). Furthermore, we also highlight both challenges and promises that emerged from recent studies that should be addressed and pursued in future investigations before ferroptosis regulation could be adopted as an effective therapeutic target in clinical practice. |
| DOI | 10.1038/s41420-021-00660-4 |
| 关键词[WOS] | GLUTATHIONE-PEROXIDASE 4 ; CELL-DEATH ; HEPATOCELLULAR-CARCINOMA ; REGULATES FERROPTOSIS ; PROMOTES FERROPTOSIS ; INHIBITS FERROPTOSIS ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; CANCER-CELLS ; PATHWAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Science and Technology Major Project of China[2018ZX10302206-003-007] ; National Science and Technology Major Project of China[2017ZX10203202-001-005] ; Municipal Natural Science Foundation of Beijing, China[7192085] ; Capital Health Research and Development of Special[2018-1-3011] ; National Natural Science Foundation of China[8170877] |
| 项目资助者 | National Science and Technology Major Project of China ; Municipal Natural Science Foundation of Beijing, China ; Capital Health Research and Development of Special ; National Natural Science Foundation of China |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| WOS记录号 | WOS:000703871400003 |
| 出版者 | SPRINGERNATURE |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/45787 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Wang, Yi; Meng, Qinghua |
| 作者单位 | 1.Capital Med Univ, Beijing You An Hosp, Dept Med Oncol, Beijing 100069, Peoples R China 2.Beijing Inst Lifeom, Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing 102206, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr & Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Gastrointestinal Oncol, Beijing 100036, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jing,Wang, Yi,Jiang, Rongtao,et al. Ferroptosis in liver disease: new insights into disease mechanisms[J]. CELL DEATH DISCOVERY,2021,7(1):9. |
| APA | Wu, Jing.,Wang, Yi.,Jiang, Rongtao.,Xue, Ran.,Yin, Xuehong.,...&Meng, Qinghua.(2021).Ferroptosis in liver disease: new insights into disease mechanisms.CELL DEATH DISCOVERY,7(1),9. |
| MLA | Wu, Jing,et al."Ferroptosis in liver disease: new insights into disease mechanisms".CELL DEATH DISCOVERY 7.1(2021):9. |
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论